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Table 2 Baseline neuropsychological characteristics and post-treatment changes according to the G1287A genotype of SLC6A2

From: Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder

  GG (=31) GA(n = 19) AA(n = 3)   GG (n = 31) GA + AA (n = 22)   
  Mean (SE) Mean (SE) Mean (SE) p-value Mean (SE) Mean (SE) Difference (95% CI) p-value
Baseline
Omission errors 66.87(4.18) 61.16(4.68) 52.00 (4.62) 0.421 66.87(4.18) 59.91 (4.12) 6.96 (-5.20-19.12) 0.256
Commission errors 54.97 (3.44) 61.74 (6.61) 53.00 (7.55) 0.567 54.97 (3.44) 60.55 (5.75) −5.58 (-18.27-7.12) 0.382
Response time 58.52 (2.98) 54.95 (3.40) 55.67 (2.85) 0.728 58.52 (2.98) 55.05 (2.94) 3.47 (-5.20-12.14) 0.425
Response time variability 66.26 (2.77) 64.95 (4.85) 67.00 (8.02) 0.961 66.26 (2.77) 65.23 (4.27) 1.03 (-8.75-10.82) 0.833
Post-treatment change (%)a
Omission errors −17.03 (3.25) −2.09 (4.96) −0.30 (4.19) 0.023 −17.03 (3.25) −1.85 (4.3) −15.19 (-25.81 to -4.57) 0.006
Commission errors −5.89 (3.74) −3.23 (5.47) −0.8 (1.83) 0.870 −5.89 (3.74) −2.90 (4.72) −2.98 (-14.95-8.99) 0.619
Response time 0.35 (6.16) −13.19 (6.23) −6.33 (7.20) 0.338 0.35 (6.16) −12.26 (5.45) 12.61 (-4.75-29.96) 0.151
Response time variability −6.89 (3.11) −4.39 (2.96) −6.70 (5.27) 0.678 −6.89 (3.11) −4.70 (2.62) −5.09 9-16.93-6.75) 0.392
  1. a ( p o s t - t r e a t m e n t C P T s c o r e - b a s e l i n e C P T s c o r e ) b a s e l i n e C P T s c o r e * 100 .
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