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Table 2 Baseline neuropsychological characteristics and post-treatment changes according to the G1287A genotype of SLC6A2

From: Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder

 

GG (=31)

GA(n = 19)

AA(n = 3)

 

GG (n = 31)

GA + AA (n = 22)

  
 

Mean (SE)

Mean (SE)

Mean (SE)

p-value

Mean (SE)

Mean (SE)

Difference (95% CI)

p-value

Baseline

Omission errors

66.87(4.18)

61.16(4.68)

52.00 (4.62)

0.421

66.87(4.18)

59.91 (4.12)

6.96 (-5.20-19.12)

0.256

Commission errors

54.97 (3.44)

61.74 (6.61)

53.00 (7.55)

0.567

54.97 (3.44)

60.55 (5.75)

−5.58 (-18.27-7.12)

0.382

Response time

58.52 (2.98)

54.95 (3.40)

55.67 (2.85)

0.728

58.52 (2.98)

55.05 (2.94)

3.47 (-5.20-12.14)

0.425

Response time variability

66.26 (2.77)

64.95 (4.85)

67.00 (8.02)

0.961

66.26 (2.77)

65.23 (4.27)

1.03 (-8.75-10.82)

0.833

Post-treatment change (%)a

Omission errors

−17.03 (3.25)

−2.09 (4.96)

−0.30 (4.19)

0.023

−17.03 (3.25)

−1.85 (4.3)

−15.19 (-25.81 to -4.57)

0.006

Commission errors

−5.89 (3.74)

−3.23 (5.47)

−0.8 (1.83)

0.870

−5.89 (3.74)

−2.90 (4.72)

−2.98 (-14.95-8.99)

0.619

Response time

0.35 (6.16)

−13.19 (6.23)

−6.33 (7.20)

0.338

0.35 (6.16)

−12.26 (5.45)

12.61 (-4.75-29.96)

0.151

Response time variability

−6.89 (3.11)

−4.39 (2.96)

−6.70 (5.27)

0.678

−6.89 (3.11)

−4.70 (2.62)

−5.09 9-16.93-6.75)

0.392

  1. a ( p o s t - t r e a t m e n t C P T s c o r e - b a s e l i n e C P T s c o r e ) b a s e l i n e C P T s c o r e * 100 .