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Table 3 Baseline neuropsychological characteristics and post-treatment changes according to the A-3081T genotype of SLC6A2

From: Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder

 

AA (n = 13)

AT (n = 28)

TT (n = 12)

 

AA (n = 13)

AT + TT (n = 40)

Difference (95% CI)

 
 

Mean (SD)

Mean (SD)

Mean (SD)

p-value

Mean (SD)

Mean (SD)

Difference (95% CI)

p-value

Baseline

Omission errors

64.69 (7.00)

61.75 (3.63)

68.42 (7.14)

0.677

64.69 (7.00)

63.75 (3.31)

0.94 (-13.16-15.05)

0.894

Commission errors

51.54 (3.79)

54.64 (3.39)

69.67 (10.02)

0.088

51.54 (3.79)

59.15 (3.91)

−7.61 (-22.10-6.88)

0.297

Response time

54.15 (4.19)

58.36 (2.47)

57.25 (6.08)

0.727

54.15 (4.19)

58.02 (2.47)

−3.87 (-13.81-6.06)

0.438

Response time variability

69.15 (7.74)

64.46 (2.18

75.42 (4.32)

0.727

69.15 (7.74)

64.75 (1.97)

4.40 (-6.74-15.55)

0.431

Post-treatment change (%)a

Omission errors

−14.12 (5.7)

−8.75 (3.78)

−11.67 (6.27)

0.728

−14.12 (5.7)

−9.63 (3.21)

−4.49 (-17.54-8.55)

0.493

Commission errors

10.05 (8.04)

−7.12 (2.92)

−14.79 (4.52)

0.007

10.05 (8.04)

−9.42 (2.49)

19.48 (6.88-32.09)

0.003

Response time

−15.82 (6.81)

1.26 (6.00)

−7.38 (10.27)

0.259

−15.82 (6.81)

−1.33 (5.18)

−14.48 (-34.35-5.39)

0.150

Response time variability

−13.12 (5.39)

−2.45 (2.33)

−6.48 (4.42)

0.150

−13.12 (5.39)

−3.66 (2.09)

−11.52 (-24.79-1.74)

0.087

  1. a ( p o s t - t r e a t m e n t C P T s c o r e - b a s e l i n e C P T s c o r e ) b a s e l i n e C P T s c o r e * 100 .