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Table 3 Baseline neuropsychological characteristics and post-treatment changes according to the A-3081T genotype of SLC6A2

From: Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder

  AA (n = 13) AT (n = 28) TT (n = 12)   AA (n = 13) AT + TT (n = 40) Difference (95% CI)  
  Mean (SD) Mean (SD) Mean (SD) p-value Mean (SD) Mean (SD) Difference (95% CI) p-value
Baseline
Omission errors 64.69 (7.00) 61.75 (3.63) 68.42 (7.14) 0.677 64.69 (7.00) 63.75 (3.31) 0.94 (-13.16-15.05) 0.894
Commission errors 51.54 (3.79) 54.64 (3.39) 69.67 (10.02) 0.088 51.54 (3.79) 59.15 (3.91) −7.61 (-22.10-6.88) 0.297
Response time 54.15 (4.19) 58.36 (2.47) 57.25 (6.08) 0.727 54.15 (4.19) 58.02 (2.47) −3.87 (-13.81-6.06) 0.438
Response time variability 69.15 (7.74) 64.46 (2.18 75.42 (4.32) 0.727 69.15 (7.74) 64.75 (1.97) 4.40 (-6.74-15.55) 0.431
Post-treatment change (%)a
Omission errors −14.12 (5.7) −8.75 (3.78) −11.67 (6.27) 0.728 −14.12 (5.7) −9.63 (3.21) −4.49 (-17.54-8.55) 0.493
Commission errors 10.05 (8.04) −7.12 (2.92) −14.79 (4.52) 0.007 10.05 (8.04) −9.42 (2.49) 19.48 (6.88-32.09) 0.003
Response time −15.82 (6.81) 1.26 (6.00) −7.38 (10.27) 0.259 −15.82 (6.81) −1.33 (5.18) −14.48 (-34.35-5.39) 0.150
Response time variability −13.12 (5.39) −2.45 (2.33) −6.48 (4.42) 0.150 −13.12 (5.39) −3.66 (2.09) −11.52 (-24.79-1.74) 0.087
  1. a ( p o s t - t r e a t m e n t C P T s c o r e - b a s e l i n e C P T s c o r e ) b a s e l i n e C P T s c o r e * 100 .
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