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Table 3 Association of seven RGS17 SNPs and four substance dependence (SD) Traits

From: Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses

SNPs Trait Race RA Frequency χ2 P obs OR (95%CI) P adj OR (95%CI) P emp
rs545323 AD AA C 0.06\0.03 6.70 0.010 1.96 (1.17−3.30) 0.013 1.96 (1.16−3.32) 0.010
  CD AA C 0.05\0.03 6.74 0.009 1.95 (1.17−3.25) 0.015 1.95 (1.16−3.28) 0.009
  OD AA C 0.07\0.03 11.27 0.001 2.55 (1.45−4.49) 0.002 2.51 (1.41−4.46) 0.003
  MjD AA C 0.06\0.03 7.30 0.007 2.10 (1.21−3.64) 0.009 2.10 (1.20−3.67) 0.009
rs516557 AD AA T 0.49\0.43 4.78 0.029 1.25 (1.02−1.52) 0.035 1.23 (1.02−1.50) 0.018
rs9371276 OD EA C 0.33\0.27 7.47 0.006 1.34 (1.09−1.66) 0.008 1.33 (1.08−1.63) 0.008
  MjD EA C 0.33\0.27 5.11 0.024 1.32 (1.04−1.62) 0.053 1.26 (1.00−1.58) 0.032
rs1933258 CD EA C 0.31\0.27 4.54 0.033 1.25 (1.02−1.54) 0.04 1.25 (1.01−1.54) 0.037
  OD EA C 0.33\0.27 8.51 0.004 1.37 (1.11−1.70) 0.004 1.36 (1.10−1.68) 0.005
  MjD EA C 0.33\0.27 5.63 0.018 1.34 (1.05−1.70) 0.036 1.29 (1.02−1.63) 0.024
rs9397585 OD EA C 0.40\0.35 4.39 0.036 1.24 (1.01−1.51) 0.02 1.27 (1.04−1.56) 0.028
  MjD EA C 0.41\0.35 4.36 0.037 1.27 (1.02−1.59) 0.035 1.28(1.02−1.61) 0.030
rs6931160 MjD AA G 0.47\0.53 6.35 0.012 0.78 (0.64−0.95) 0.015 0.79 (0.65−0.95) 0.016
  OD EA C 0.48\0.42 5.14 0.023 1.25 (1.03−1.51) 0.019 1.26 (1.04−1.54) 0.018
  CD AA G 0.49\0.53 4.56 0.033 0.83 (0.7−0.99) 0.036 0.83 (0.70−0.99) 0.028
rs596359 AD AA G 0.35\0.29 7.82 0.005 1.31 (1.08−1.58) 0.008 1.29 (1.07−1.56) 0.005
  AD EA G 0.50\0.44 6.37 0.012 1.27 (1.05−1.52) 0.011 1.27 (1.06−1.53) 0.014
  CD AA G 0.34\0.29 6.77 0.009 1.28 (1.06−1.54) 0.011 1.27 (1.06−1.53) 0.009
  CD EA G 0.51\0.44 6.91 0.009 1.28 (1.06−1.54) 0.008 1.29 (1.07−1.56) 0.006
  OD AA G 0.35\0.29 6.50 0.011 1.34 (1.07−1.69) 0.023 1.31 (1.04−1.63) 0.019
  OD EA G 0.5\0.44 5.54 0.019 1.26 (1.04−1.52) 0.01 1.29 (1.06−1.57) 0.013
  MjD AA G 0.35\0.29 8.05 0.005 1.35 (1.10−1.67) 0.008 1.33 (1.08−1.63) 0.006
  MjD EA G 0.51\0.44 5.70 0.017 1.30 (1.05−1.62) 0.015 1.31 (1.05−1.63) 0.013
  1. AA, African Americans; EA, European Americans. AD, alcohol dependence; CD, cocaine dependence; OD, opioid dependence; MjD, Marijuana dependence.
  2. Pobs, observed P values using Pearson’s Chi-square tests; Padj, adjusted P values using multivariable logistic regression analyses after adjustment for sex, age and ancestry proportion under the additive model; Pemp, empirical P values using permutation-based tests to correct for multiple testing.
  3. RA, reference alleles; 95% CI, 95% confidence interval.