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Table 3 Association of seven RGS17 SNPs and four substance dependence (SD) Traits

From: Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses

SNPs

Trait

Race

RA

Frequency

χ2

P obs

OR (95%CI)

P adj

OR (95%CI)

P emp

rs545323

AD

AA

C

0.06\0.03

6.70

0.010

1.96 (1.17−3.30)

0.013

1.96 (1.16−3.32)

0.010

 

CD

AA

C

0.05\0.03

6.74

0.009

1.95 (1.17−3.25)

0.015

1.95 (1.16−3.28)

0.009

 

OD

AA

C

0.07\0.03

11.27

0.001

2.55 (1.45−4.49)

0.002

2.51 (1.41−4.46)

0.003

 

MjD

AA

C

0.06\0.03

7.30

0.007

2.10 (1.21−3.64)

0.009

2.10 (1.20−3.67)

0.009

rs516557

AD

AA

T

0.49\0.43

4.78

0.029

1.25 (1.02−1.52)

0.035

1.23 (1.02−1.50)

0.018

rs9371276

OD

EA

C

0.33\0.27

7.47

0.006

1.34 (1.09−1.66)

0.008

1.33 (1.08−1.63)

0.008

 

MjD

EA

C

0.33\0.27

5.11

0.024

1.32 (1.04−1.62)

0.053

1.26 (1.00−1.58)

0.032

rs1933258

CD

EA

C

0.31\0.27

4.54

0.033

1.25 (1.02−1.54)

0.04

1.25 (1.01−1.54)

0.037

 

OD

EA

C

0.33\0.27

8.51

0.004

1.37 (1.11−1.70)

0.004

1.36 (1.10−1.68)

0.005

 

MjD

EA

C

0.33\0.27

5.63

0.018

1.34 (1.05−1.70)

0.036

1.29 (1.02−1.63)

0.024

rs9397585

OD

EA

C

0.40\0.35

4.39

0.036

1.24 (1.01−1.51)

0.02

1.27 (1.04−1.56)

0.028

 

MjD

EA

C

0.41\0.35

4.36

0.037

1.27 (1.02−1.59)

0.035

1.28(1.02−1.61)

0.030

rs6931160

MjD

AA

G

0.47\0.53

6.35

0.012

0.78 (0.64−0.95)

0.015

0.79 (0.65−0.95)

0.016

 

OD

EA

C

0.48\0.42

5.14

0.023

1.25 (1.03−1.51)

0.019

1.26 (1.04−1.54)

0.018

 

CD

AA

G

0.49\0.53

4.56

0.033

0.83 (0.7−0.99)

0.036

0.83 (0.70−0.99)

0.028

rs596359

AD

AA

G

0.35\0.29

7.82

0.005

1.31 (1.08−1.58)

0.008

1.29 (1.07−1.56)

0.005

 

AD

EA

G

0.50\0.44

6.37

0.012

1.27 (1.05−1.52)

0.011

1.27 (1.06−1.53)

0.014

 

CD

AA

G

0.34\0.29

6.77

0.009

1.28 (1.06−1.54)

0.011

1.27 (1.06−1.53)

0.009

 

CD

EA

G

0.51\0.44

6.91

0.009

1.28 (1.06−1.54)

0.008

1.29 (1.07−1.56)

0.006

 

OD

AA

G

0.35\0.29

6.50

0.011

1.34 (1.07−1.69)

0.023

1.31 (1.04−1.63)

0.019

 

OD

EA

G

0.5\0.44

5.54

0.019

1.26 (1.04−1.52)

0.01

1.29 (1.06−1.57)

0.013

 

MjD

AA

G

0.35\0.29

8.05

0.005

1.35 (1.10−1.67)

0.008

1.33 (1.08−1.63)

0.006

 

MjD

EA

G

0.51\0.44

5.70

0.017

1.30 (1.05−1.62)

0.015

1.31 (1.05−1.63)

0.013

  1. AA, African Americans; EA, European Americans. AD, alcohol dependence; CD, cocaine dependence; OD, opioid dependence; MjD, Marijuana dependence.
  2. Pobs, observed P values using Pearson’s Chi-square tests; Padj, adjusted P values using multivariable logistic regression analyses after adjustment for sex, age and ancestry proportion under the additive model; Pemp, empirical P values using permutation-based tests to correct for multiple testing.
  3. RA, reference alleles; 95% CI, 95% confidence interval.
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Behavioral and Brain Functions

ISSN: 1744-9081

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