Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses

Table 4 Association of RGS17 haplotypes and four substance dependence (SD) traits

LD Blocks	Haplotypes	Phenotypes	Frequencies	χ²	P _obs	P _emp
(AAs)			(Case/control)
RGS17_I	GATTC	AD	0.053\ 0.032	5.09	0.024	0.319
	GATTC	CD	0.053\ 0.032	5.41	0.020	0.267
	GATTC	OD	0.067\ 0.032	9.25	0.002	0.026
	GATTC	MjD	0.057\ 0.032	5.95	0.015	0.178
	GTTCT	AD	0.015\ 0.029	5.83	0.016	0.222
	GTTCT	CD	0.016\ 0.029	5.44	0.020	0.265
	GTTCT	OD	0.010\ 0.029	6.65	0.010	0.106
	GTTCT	MjD	0.010\ 0.029	8.44	0.004	0.048
RGS17_II	CCT	OD	0.056\ 0.032	4.49	0.034	0.375
	TGT	OD	0.437\ 0.491	4.16	0.042	0.436
	TGT	MjD	0.440\ 0.491	4.35	0.037	0.405
RGS17_III	CC	MjD	0.528\ 0.472	5.35	0.021	0.240
LD Blocks	Haplotypes	Phenotypes	Frequencies	χ ²	P _obs	P _emp
(EAs)			(Case/Control)
RGS17_I	GTCTT	AD	0.211\ 0.258	5.75	0.017	0.159
	GTCTT	CD	0.206\ 0.258	7.14	0.008	0.070
	GTCTT	OD	0.210\ 0.258	5.56	0.018	0.169
RGS17_II	CCCC	CD	0.302\ 0.260	4.07	0.044	0.387
	CCCC	OD	0.324\ 0.260	8.26	0.004	0.028
	CCCC	MjD	0.309\ 0.260	3.98	0.046	0.345
RGS17_III	CC	OD	0.471\ 0.420	4.56	0.033	0.317

AD, alcohol dependence; CD, cocaine dependence; OD, opioid dependence; MjD, marijuana dependence.
P_obs, observed P values using Pearson’s Chi-squared tests.
P_emp, empirical P values using permutation-based tests for multiple testing corrections.

ISSN: 1744-9081