Skip to main content

Advertisement

Table 4 Association of RGS17 haplotypes and four substance dependence (SD) traits

From: Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses

LD Blocks Haplotypes Phenotypes Frequencies χ2 P obs P emp
(AAs)    (Case/control)    
RGS17_I GATTC AD 0.053\ 0.032 5.09 0.024 0.319
  GATTC CD 0.053\ 0.032 5.41 0.020 0.267
  GATTC OD 0.067\ 0.032 9.25 0.002 0.026
  GATTC MjD 0.057\ 0.032 5.95 0.015 0.178
  GTTCT AD 0.015\ 0.029 5.83 0.016 0.222
  GTTCT CD 0.016\ 0.029 5.44 0.020 0.265
  GTTCT OD 0.010\ 0.029 6.65 0.010 0.106
  GTTCT MjD 0.010\ 0.029 8.44 0.004 0.048
RGS17_II CCT OD 0.056\ 0.032 4.49 0.034 0.375
  TGT OD 0.437\ 0.491 4.16 0.042 0.436
  TGT MjD 0.440\ 0.491 4.35 0.037 0.405
RGS17_III CC MjD 0.528\ 0.472 5.35 0.021 0.240
LD Blocks Haplotypes Phenotypes Frequencies χ 2 P obs P emp
(EAs)    (Case/Control)    
RGS17_I GTCTT AD 0.211\ 0.258 5.75 0.017 0.159
  GTCTT CD 0.206\ 0.258 7.14 0.008 0.070
  GTCTT OD 0.210\ 0.258 5.56 0.018 0.169
RGS17_II CCCC CD 0.302\ 0.260 4.07 0.044 0.387
  CCCC OD 0.324\ 0.260 8.26 0.004 0.028
  CCCC MjD 0.309\ 0.260 3.98 0.046 0.345
RGS17_III CC OD 0.471\ 0.420 4.56 0.033 0.317
  1. AD, alcohol dependence; CD, cocaine dependence; OD, opioid dependence; MjD, marijuana dependence.
  2. Pobs, observed P values using Pearson’s Chi-squared tests.
  3. P emp , empirical P values using permutation-based tests for multiple testing corrections.