Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia

Table 2 Serotonin transporter ( SLC6A4 ) single nucleotide polymorphisms (SNPs) investigated in suicidal attempters (SA) and non-suicidal (No SA) attempters with a schizophrenia diagnosis

SNP	SNP localization	Position		MAF	Base	Genotype counts			Allele association		Genotype association
						(SA/No SA)				OR		OR	OR
			(no of bases)		(1/2)	1 1	1 2	2 2	P-value	2 vs 1	P-value	12 vs 11	22 vs 11
Rs1042173	3'-UTR	28525011		0.47	A/C	70/125	144/195	75/104	0.218	1.14	0.27	1.34	1.29
Rs4583306	Intron 8	28538715	13704	0.03	A/G	77/134	150/201	60/88	0.335	1.11	0.29	1.33	1.20
Rs140700	Intron 5	28543389	4674	0.08	C/T	243/348	43/79	2/0	0.560	0.89	0.11	0.80	2.26E9
Rs2020942	Intron 2	28546914	3525	0.39	C/T	108/157	135/201	44/68	0.777	0.97	0.94	0.99	0.93
Rs12150214	Intron 1	28550888	3974	0.17	G/C	213/301	67/117	10/8	0.735	0.95	0.23	0.81	1.72
Rs4251417	Intron 1	28551858	970	0.10	C/T	227/347	55/77	4/1	0.338	1.19	0.18	1.07	6.26
Rs16965628	Intron 1	28555425	3567	0.05	G/C	272/374	15/51	0/1	0.0009 (0.01)	0.39	0.004 (0.02)	0.40	3.92E-5

The table shows nominal allele and genotype association results with gender and country as covariates.
Chromosomal position, minor allele frequency (MAF), SNP-alleles (Base), genotype counts, P-values and odds ratios (OR) for allele and genotype association for the seven SNP markers are presented in the table. Global significant P-values are shown in parenthesis.

ISSN: 1744-9081