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Table 1 SCZ-associated variants on chromosome 1 that could meet or do not meet the criterion in the Top 45 genes at the SZGene Database[19](Updated Dec 23, 2011)

From: Paradox of schizophrenia genetics: is a paradigm shift occurring?

Genes and SNPs

Location

Allele (min/maj)

m A

m U

OR

d

MHTFR

1p36.22

     

rs1801133

 

T*/C

0.3532

0.3211

1.15

0.032

GRIK3

1p34.3

     

rs6691840

 

G*/T

0.2600

0.2226

1.25

0.037

PDE4B

1p31.3

     

rs910694

 

C/T*

0.5780

0.5477

1.30

0.030

GSTM1

1p13.3

     

GSTM1*0

 

ins-allele/ del-allele*

0.7546

0.7140

1.35

0.041

RGS4

1q23.3

     

rs2661319

 

A/G*

0.4920

0.4744

1.08

0.0176

IL10

1q32.1

     

rs1800896

 

G*/A

0.3056

0.2657

1.42

0.040

PLXNA2

1q32.2

A/G

    

rs841865

 

A/G*

0.8434

0.8001

1.32

0.043

rs1327175

 

G/C*

0.92840

0.91243

1.32

0.016

DISC1

1q42.3

     

rs3737597

 

A*/G

0.03069

0.01735

1.80

0.013

rs999710

 

A*/G

0.3989

0.3819

1.07

0.0170

  1. Four variants at the three loci (RGS4, PLXNA2, DISC1) on chromosome 1 could meet the criterion under the assumption that the mutation rates at those loci are near the upper limit in the autosomes and the X chromosome. All of them are located on 1q, while four protective genes (MHTFR, GRIK3, PDE4B, GSTM1) are on 1p.
  2. *alleles associated with SCZ.
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Behavioral and Brain Functions

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