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Table 1 SCZ-associated variants on chromosome 1 that could meet or do not meet the criterion in the Top 45 genes at the SZGene Database[19](Updated Dec 23, 2011)

From: Paradox of schizophrenia genetics: is a paradigm shift occurring?

Genes and SNPs Location Allele (min/maj) m A m U OR d
MHTFR 1p36.22      
rs1801133   T*/C 0.3532 0.3211 1.15 0.032
GRIK3 1p34.3      
rs6691840   G*/T 0.2600 0.2226 1.25 0.037
PDE4B 1p31.3      
rs910694   C/T* 0.5780 0.5477 1.30 0.030
GSTM1 1p13.3      
GSTM1*0   ins-allele/ del-allele* 0.7546 0.7140 1.35 0.041
RGS4 1q23.3      
rs2661319   A/G* 0.4920 0.4744 1.08 0.0176
IL10 1q32.1      
rs1800896   G*/A 0.3056 0.2657 1.42 0.040
PLXNA2 1q32.2 A/G     
rs841865   A/G* 0.8434 0.8001 1.32 0.043
rs1327175   G/C* 0.92840 0.91243 1.32 0.016
DISC1 1q42.3      
rs3737597   A*/G 0.03069 0.01735 1.80 0.013
rs999710   A*/G 0.3989 0.3819 1.07 0.0170
  1. Four variants at the three loci (RGS4, PLXNA2, DISC1) on chromosome 1 could meet the criterion under the assumption that the mutation rates at those loci are near the upper limit in the autosomes and the X chromosome. All of them are located on 1q, while four protective genes (MHTFR, GRIK3, PDE4B, GSTM1) are on 1p.
  2. *alleles associated with SCZ.