Table 3 Associations of rs3758653 and rs936465 with average DRD4 DNA methylation in post-mortem brain tissue
SNP | Tissue | N | Mean AA (N) | Mean AB (N) | Mean BB (N) | F | P-value |
|---|---|---|---|---|---|---|---|
rs3758653 | Striatum | 13 | 0.47 (2) | 0.57 (3) | 0.51 (8) | 0.03 | 0.433 |
Mid-brain | 8 | 0.38 (1) | 0.53 (2) | 0.48 (5) | 0.06 | 0.590 | |
Cerebellum | 9 | 0.51 (2) | NA (0) | 0.53 (7) | 0.10 | 0.382 | |
STG | 12 | 0.52 (1) | 0.57 (3) | 0.52 (8) | 3.05 | 0.944 | |
SFG | 9 | 0.48 (2) | 0.59 (1) | 0.57 (7) | 6.51 | 0.017 | |
rs936465 | Striatum | 13 | 0.56 (3) | 0.5 (7) | 0.53 (3) | 0.09 | 0.384 |
Mid-brain | 8 | 0.52 (3) | 0.46 (4) | 0.42 (1) | 5.82 | 0.038 | |
Cerebellum | 9 | 0.56 (3) | 0.51 (3) | 0.5 (3) | 3.02 | 0.063 | |
STG | 12 | 0.55 (5) | 0.53 (5) | 0.52 (2) | 6.31 | 0.015 | |
SFG | 10 | 0.6 (3) | 0.54 (4) | 0.53 (3) | 2.93 | 0.063 |