Figure 2

Effects of intermittent ethanol and MDMA administration during adolescence on latency to reach the goal on each trail in the Hebb-Williams maze (2a for the easy and 2b for the difficult mazes). The mazes were classified as easy (1, 3 and 4) or difficult (5 and 8). Mice were treated with Saline (Sal), 10 or 20 mg/kg of MDMA (M10 and M20), 1.25 g/kg of ethanol (E1.25), or 1.25 g/kg of ethanol + 10 or 20 mg/kg of MDMA (E1.25 + M10 and E1.25 + M20). Data are presented as mean values ± S.E.M. Differences with respect to the first trial * p < 0.05 in the easy and 0.001 in the difficult.