Effect of intermittent exposure to ethanol and MDMA during adolescence on learning and memory in adult mice

Table 2 Effects of intermittent ethanol and MDMA administration during adolescence on the concentration of brain monoamines in the striatum and hippocampus in mice

	Sal	M10	M20	E1.25	E1.25+M10	E1.25+M20
*Striatum*
DA	12364±1015	13315±981	7454±713***	11962±1176	9471±1929***	9850±1041***
DOPAC	1519±210	927±102	719±53++	1082±119	1069±202	765±106++
DATurnover	0.12±0.02	0.07±0.001**	0.1±0.01	0.09±0.01*	0.11±0.01	0.08±0.001
5-HT	924±76	1110±95	825±72	1247±98+	1128±167+	1200±289+
5-HIIA	547±86	441±16	450±47	590±101	859±234	507±57
5-HT Turnover	0.59±0.07	0.4±0.02	0.6±0.06	0.51±0.08	0.75±0.17	0.53±0.18
*Hippocampus*
5--‐HT	534±37	570±67	489±179	959±207+	560±48+	635±56+
5--‐HIIA	504±85	613±111	541±65	1109±375	496±69	637±37

Animals were treated during adolescence with Saline (Sal), 10 mg/kg of MDMA (M10), 20 mg/kg of MDMA (M20), 1.25 mg/kg of ethanol (E1.25), 1.25 mg/kg of ethanol+10 mg/kg of MDMA (E1.25+M10), or 1.25 mg/kg of ethanol+20 mg/kg of MDMA (E1.25+M20). Data are presented in means with ±S.E.M. Differences with respect to the saline group *p< 0.05, ** p< 0.02, *** p< 0.001; differences with respect to non-EtOH treated groups + p< 0.03; differences with respect to non-MDMA treated groups ++ p< 0.001.

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