Atlas-based white matter analysis in individuals with velo-cardio-facial syndrome (22q11.2 deletion syndrome) and unaffected siblings

Radoeva, Petya D; Coman, Ioana L; Antshel, Kevin M; Fremont, Wanda; McCarthy, Christopher S; Kotkar, Ashwini; Wang, Dongliang; Shprintzen, Robert J; Kates, Wendy R

doi:10.1186/1744-9081-8-38

Table 3 Correlations between neuropsychological measures and the Axial Diffusivity of white matter tracts in the Left Hemisphere across all study participants

From: Atlas-based white matter analysis in individuals with velo-cardio-facial syndrome (22q11.2 deletion syndrome) and unaffected siblings

Domain	Measure	Left Hemisphere
		Frontal/Temp			Parietal/Occipital A/P Long Tracts Cer
		CGC	SCR	RLIC	EC	PTR	PCR	SLF	IFO	SS	SCP
Memory & Attention	Digit Span FW	0.19	0.15	0.13	0.29	0.19	0.07	0.14	0.22	0.19	0.35 ^*
	Digit Span BW	0.15	0.15	0.17	0.08	0.37 ^*	0.20	0.23	0.20	0.21	0.34
	Visual Span FW	0.33	0.28	0.31	0.25	0.36 ^*	0.47 ^**	0.40 ^*	0.28	0.29	0.25
	Visual Span BW	0.34	0.28	0.43^*	0.29	0.52 ^**	0.48 ^**	0.47 ^**	0.40 ^*	0.38 ^*	0.27
	CVLT_List A, Trials 1–5	0.07	0.18	0.08	0.09	0.30	0.35	0.37 ^*	0.14	0.16	0.21
Executive Function	WCST Perseverative Error	0.18	0.30	0.33	0.21	0.45 ^**	0.43 ^*	0.50 ^**	0.27	0.33	0.34
	BRIEF Behavioral Regulation	0.00	−0.18	−0.17	−0.24	−0.42 ^*	−0.28	−0.30	−0.23	−0.16	−0.30
	BRIEF Metacognition	−0.15	−0.15	−0.22	−0.26	−0.51 ^**	−0.31	−0.34	−0.32	−0.18	−0.27
Social Cognition	BASC Social Skills	0.08	0.16	0.11	0.23	0.24	0.28	0.29	0.17	0.21	0.26
Socialization	Vineland Soc Skills	0.01	0.19	0.21	0.28	0.45 ^**	0.37 ^*	0.40 ^*	0.27	0.33	0.29
	SRS	−0.08	−0.25	−0.26	−0.27	−0.49 ^**	−0.42 ^*	−0.42 ^*	−0.30	−0.25	−0.33
Emotion	Emotion Recognition	0.17	0.24	0.33	0.20	0.30	0.27	0.33	0.20	0.10	0.22
Psychiatric	BASC Anxiety	−0.06	−0.21	−0.08	−0.07	−0.31	−0.28	−0.27	−0.11	−0.19	−0.34
Symptoms	BASC Atypicality	−0.01	−0.30	−0.25	−0.24	−0.37 ^*	−0.35	−0.36 ^*	−0.27	−0.15	−0.30
	CGAS	0.07	0.24	0.06	0.12	0.39 ^*	0.33	0.37 ^*	0.21	0.16	0.26
Overall	Verbal IQ	0.32	0.34	0.47 ^**	0.35 ^*	0.52 ^**	0.54 ^**	0.55 ^**	0.36 ^*	0.43 ^*	0.43 ^*
Cognition	Performance IQ	0.39 ^*	0.38 ^*	0.50 ^**	0.35 ^*	0.62 ^***	0.55 ^**	0.54 ^**	0.38 ^*	0.45 ^*	0.42 ^*

The subset of WM tracts included in this table had significantly different AD between individuals with VCFS and unaffected siblings, p_FDR<0.05. The R values for the correlations are given, and corresponding FDR-corrected P-values are indicated with a superscript according to the legend below the table. No significance was found for the Non-Perseverative Error Standard Score of WCST, the standard score for List A, trial 5, and AD of the ACR tract in the left hemisphere: thus, these measures were not included in this table.
Abbreviations BW: Backward; FW: Forward; CVLT: California Verbal Learning Test; WCST: Wisconsin Card Sorting Test; BRIEF: Behavior Rating Inventory of Executive Functioning; SRS: Social Responsiveness Scale; BASC: Behavior Assessment System for Children; CGAS: Children's Global Assessment Scale; IQ: Intelligence Quotient. Abbreviations for the white matter tracts are given in the list of Abbreviations at the end of the paper. A/P Long Tracts: Anterior-Poster Long Tracts; Cer: cerebellum.
* p_FDR < 0.05.
^**p_FDR < 0.01.
^***p_FDR < 0.001.

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ISSN: 1744-9081

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