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Table 3 Correlations between neuropsychological measures and the Axial Diffusivity of white matter tracts in the Left Hemisphere across all study participants

From: Atlas-based white matter analysis in individuals with velo-cardio-facial syndrome (22q11.2 deletion syndrome) and unaffected siblings

Domain Measure Left Hemisphere
   Frontal/Temp Parietal/Occipital A/P Long Tracts Cer
   CGC SCR RLIC EC PTR PCR SLF IFO SS SCP
Memory & Attention Digit Span FW 0.19 0.15 0.13 0.29 0.19 0.07 0.14 0.22 0.19 0.35 *
  Digit Span BW 0.15 0.15 0.17 0.08 0.37 * 0.20 0.23 0.20 0.21 0.34
  Visual Span FW 0.33 0.28 0.31 0.25 0.36 * 0.47 ** 0.40 * 0.28 0.29 0.25
  Visual Span BW 0.34 0.28 0.43* 0.29 0.52 ** 0.48 ** 0.47 ** 0.40 * 0.38 * 0.27
  CVLT_List A, Trials 1–5 0.07 0.18 0.08 0.09 0.30 0.35 0.37 * 0.14 0.16 0.21
Executive Function WCST Perseverative Error 0.18 0.30 0.33 0.21 0.45 ** 0.43 * 0.50 ** 0.27 0.33 0.34
  BRIEF Behavioral Regulation 0.00 −0.18 −0.17 −0.24 −0.42 * −0.28 −0.30 −0.23 −0.16 −0.30
  BRIEF Metacognition −0.15 −0.15 −0.22 −0.26 −0.51 ** −0.31 −0.34 −0.32 −0.18 −0.27
Social Cognition BASC Social Skills 0.08 0.16 0.11 0.23 0.24 0.28 0.29 0.17 0.21 0.26
Socialization Vineland Soc Skills 0.01 0.19 0.21 0.28 0.45 ** 0.37 * 0.40 * 0.27 0.33 0.29
  SRS −0.08 −0.25 −0.26 −0.27 −0.49 ** −0.42 * −0.42 * −0.30 −0.25 −0.33
Emotion Emotion Recognition 0.17 0.24 0.33 0.20 0.30 0.27 0.33 0.20 0.10 0.22
Psychiatric BASC Anxiety −0.06 −0.21 −0.08 −0.07 −0.31 −0.28 −0.27 −0.11 −0.19 −0.34
Symptoms BASC Atypicality −0.01 −0.30 −0.25 −0.24 −0.37 * −0.35 −0.36 * −0.27 −0.15 −0.30
  CGAS 0.07 0.24 0.06 0.12 0.39 * 0.33 0.37 * 0.21 0.16 0.26
Overall Verbal IQ 0.32 0.34 0.47 ** 0.35 * 0.52 ** 0.54 ** 0.55 ** 0.36 * 0.43 * 0.43 *
Cognition Performance IQ 0.39 * 0.38 * 0.50 ** 0.35 * 0.62 *** 0.55 ** 0.54 ** 0.38 * 0.45 * 0.42 *
  1. The subset of WM tracts included in this table had significantly different AD between individuals with VCFS and unaffected siblings, p FDR <0.05. The R values for the correlations are given, and corresponding FDR-corrected P-values are indicated with a superscript according to the legend below the table. No significance was found for the Non-Perseverative Error Standard Score of WCST, the standard score for List A, trial 5, and AD of the ACR tract in the left hemisphere: thus, these measures were not included in this table.
  2. Abbreviations BW: Backward; FW: Forward; CVLT: California Verbal Learning Test; WCST: Wisconsin Card Sorting Test; BRIEF: Behavior Rating Inventory of Executive Functioning; SRS: Social Responsiveness Scale; BASC: Behavior Assessment System for Children; CGAS: Children's Global Assessment Scale; IQ: Intelligence Quotient. Abbreviations for the white matter tracts are given in the list of Abbreviations at the end of the paper. A/P Long Tracts: Anterior-Poster Long Tracts; Cer: cerebellum.
  3. * p FDR  < 0.05.
  4. **p FDR  < 0.01.
  5. ***p FDR  < 0.001.