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Table 4 Correlations between neuropsychological measures and Axial Diffusivity of white matter tracts in the Right Hemisphere across all study participants

From: Atlas-based white matter analysis in individuals with velo-cardio-facial syndrome (22q11.2 deletion syndrome) and unaffected siblings

Domain

Measure

Right Hemisphere

  

Frontal/Temp Parietal/Occipital A/P Long Tracts Cer

  

CGC

SCR

PTR

PCR

SLF

IFO

SCP

Memory & Attention

Digit Span FW

0.23

0.20

0.25

0.17

0.16

0.25

0.36 *

 

Digit Span BW

0.24

0.12

0.38 *

0.26

0.30

0.36 *

0.44 *

 

Visual Span FW

0.42 *

0.38 *

0.29

0.48 **

0.47 **

0.48 **

0.25

 

Visual Span BW

0.38 *

0.24

0.25

0.51

0.57 **

0.61 ***

0.29

 

CVLT_List A, , Trials 1–5

0.18

0.17

0.29

0.36 *

0.38 *

0.25

0.26

Executive Function

WCST Perseverative Error

0.29

0.29

0.37 *

0.48 **

0.58 **

0.48 **

0.32

 

BRIEF Behavioral Regulation

−0.17

−0.31

−0.28

−0.40 *

−0.48 **

−0.34

−0.17

 

BRIEF Metacognition

−0.22

−0.36 *

−0.30

−0.45 **

−0.53 **

−0.41 *

−0.18

Social Cognition

BASC Social Skills

0.14

0.14

0.23

0.29

0.43 *

0.24

0.22

Socialization

Vineland Soc Skills

0.17

0.22

0.27

0.38 *

0.54 **

0.41 *

0.31

 

SRS

−0.24

−0.34

−0.27

−0.49 **

0.41 *

−0.44 *

−0.27

Emotion

Emotion Recognition

0.24

0.15

0.17

0.28

0.38 *

0.41 *

0.23

Psychiatric

BASC Anxiety

−0.13

−0.23

−0.19

−0.34

−0.39 *

−0.22

−0.31

Symptoms

BASC Atypicality

−0.16

−0.38 *

−0.26

−0.44 *

−0.48 **

−0.35 *

−0.23

 

CGAS

0.11

0.29

0.31

0.44 *

0.57 **

0.39 *

0.33

Overall

Verbal IQ

0.44 *

0.24

0.46 **

0.48 **

0.60 ***

0.52 **

0.47 **

Cognition

Performance IQ

0.49 **

0.37 *

0.45 **

0.58 **

0.63 ***

0.62 ***

0.47 **

  1. *p FDR  < 0.05.
  2. **p FDR  < 0.01.
  3. ***p FDR  < 0.001.
  4. The subset of WM tracts included in this table had significantly different AD between individuals with VCFS and unaffected siblings (p FDR  < 0.05). For abbreviations and further details, see the legend of Table 3.