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Table 4 Scores achieved on the Wisconsin Card Sorting Test (WCST) by GRM3 SNP genotype

From: Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate levels and neurocognition in non-smoking, active alcoholics

WCST parameters rs6465084 rs1468412 rs2299225
A/A group G carrier group T carrier group A/A group T/T group G/T group
Alcoholic group (n = 31) (n = 18) (n = 19) (n = 30) (n = 37) (n = 12)
Number of corrects 28.48 ± 3.16 a 33.61 ± 2.03 28.95 ± 3.58 b 31.27 ± 3.60 30.05 ± 4.05 31.33 ± 2.42
Perseverative errors 12.68 ± 3.54 a 9.44 ± 1.82 12.53 ± 3.91 10.83 ± 2.90 11.59 ± 3.57 11.17 ± 2.89
Random errors 6.87 ± 2.87 a 5.00 ± 1.68 6.58 ± 3.06 5.93 ± 2.36 6.41 ± 2.87 5.50 ± 1.68
Categories completed 1.10 ± 0.98 a 3.78 ± 0.81 1.42 ± 1.35 b 2.50 ± 1.61 2.00 ± 1.51 2.33 ± 1.87
  F = 31.35, v1 = 4, v2 = 44, P < 0.001 c F = 1.61, v1 = 4, v2 = 44, P =0.188 F = 0.47, v1 = 4, v2 = 44, P = 0.757
Control group (n = 29) (n = 16) (n = 18) (n = 27) (n = 30) (n = 15)
Number of corrects 37.72 ± 2.46 37.88 ± 2.28 37.67 ± 2.43 37.85 ± 2.38 37.67 ± 2. 50 38.00 ± 2.17
Preservative errors 5.25 ± 1.88 6.48 ± 2.63 6.17 ± 2. 43 5.96 ± 2.49 6.30 ± 2.56 5.53 ± 2.17
Random errors 4.88 ± 1.20 a 3.79 ± 1.26 4.17 ± 1.34 4.19 ± 1.36 4.03 ± 1.19 4.47 ± 1.60
Categories completed 5.00 ± 0.60 4.81 ± 0.75 4.78 ± 0.73 5.04 ± 0.59 4.93 ± 0.64 4.93 ± 0.70
  F = 3.28, v1 = 3, v2 = 41, P = 0.030 d F = 0.72, v1 = 3, v2 = 41, P =0.543 F = 0.51, v1 = 3, v2 = 41, P = 0.676
  F = 3.43,v1 = 4,v2 = 89,P = 0.012 e F = 0.73,v1 = 4,v2 = 89,P = 0.574 F = 0.58,v1 = 4,v2 = 89,P = 0.681
  1. a Value is statistically significantly different (P < 0.01) than that found in the comparison group for that SNP.
  2. b Value is statistically significantly lower (P < 0.05) than that found in the comparison group for that SNP.
  3. c The A/A genotype group for SNP rs6465084 was significantly different from the G carriers for the variables of WCST scores among alcoholics.
  4. d The A/A genotype group for SNP rs6465084 was significantly different from the G carriers for the variables of WCST scores among controls.
  5. e The A/A genotype group for SNP rs6465084 was significantly different from the G carriers for the variables of WCST scores in all the subjects.