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Table 4 Scores achieved on the Wisconsin Card Sorting Test (WCST) by GRM3 SNP genotype

From: Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate levels and neurocognition in non-smoking, active alcoholics

WCST parameters

rs6465084

rs1468412

rs2299225

A/A group

G carrier group

T carrier group

A/A group

T/T group

G/T group

Alcoholic group

(n = 31)

(n = 18)

(n = 19)

(n = 30)

(n = 37)

(n = 12)

Number of corrects

28.48 ± 3.16 a

33.61 ± 2.03

28.95 ± 3.58 b

31.27 ± 3.60

30.05 ± 4.05

31.33 ± 2.42

Perseverative errors

12.68 ± 3.54 a

9.44 ± 1.82

12.53 ± 3.91

10.83 ± 2.90

11.59 ± 3.57

11.17 ± 2.89

Random errors

6.87 ± 2.87 a

5.00 ± 1.68

6.58 ± 3.06

5.93 ± 2.36

6.41 ± 2.87

5.50 ± 1.68

Categories completed

1.10 ± 0.98 a

3.78 ± 0.81

1.42 ± 1.35 b

2.50 ± 1.61

2.00 ± 1.51

2.33 ± 1.87

 

F = 31.35, v1 = 4, v2 = 44, P < 0.001 c

F = 1.61, v1 = 4, v2 = 44, P =0.188

F = 0.47, v1 = 4, v2 = 44, P = 0.757

Control group

(n = 29)

(n = 16)

(n = 18)

(n = 27)

(n = 30)

(n = 15)

Number of corrects

37.72 ± 2.46

37.88 ± 2.28

37.67 ± 2.43

37.85 ± 2.38

37.67 ± 2. 50

38.00 ± 2.17

Preservative errors

5.25 ± 1.88

6.48 ± 2.63

6.17 ± 2. 43

5.96 ± 2.49

6.30 ± 2.56

5.53 ± 2.17

Random errors

4.88 ± 1.20 a

3.79 ± 1.26

4.17 ± 1.34

4.19 ± 1.36

4.03 ± 1.19

4.47 ± 1.60

Categories completed

5.00 ± 0.60

4.81 ± 0.75

4.78 ± 0.73

5.04 ± 0.59

4.93 ± 0.64

4.93 ± 0.70

 

F = 3.28, v1 = 3, v2 = 41, P = 0.030 d

F = 0.72, v1 = 3, v2 = 41, P =0.543

F = 0.51, v1 = 3, v2 = 41, P = 0.676

 

F = 3.43,v1 = 4,v2 = 89,P = 0.012 e

F = 0.73,v1 = 4,v2 = 89,P = 0.574

F = 0.58,v1 = 4,v2 = 89,P = 0.681

  1. a Value is statistically significantly different (P < 0.01) than that found in the comparison group for that SNP.
  2. b Value is statistically significantly lower (P < 0.05) than that found in the comparison group for that SNP.
  3. c The A/A genotype group for SNP rs6465084 was significantly different from the G carriers for the variables of WCST scores among alcoholics.
  4. d The A/A genotype group for SNP rs6465084 was significantly different from the G carriers for the variables of WCST scores among controls.
  5. e The A/A genotype group for SNP rs6465084 was significantly different from the G carriers for the variables of WCST scores in all the subjects.