Immunization with DAT fragments is associated with long-term striatal impairment, hyperactivity and reduced cognitive flexibility in mice

Table 3 Neuro-chemical parameters in striata of VEH and DAT-i mice

Parameter	DA	DOPAC	HVA
VEH inflexible (“flat”)	317.5 ± 47.5	91.3 ± 22.0	59.5 ± 5.7
VEH flexible (“steep”)	368.5 ± 35.9	77.2 ± 20.0	65.4 ± 2.5
DAT-i flexible (“slow”)	320.8 ± 30.4	53.8 ± 14.9	75.2 ± 9.7 *
DAT-i inflexible (“stuck”)	452.3 ± 90.9	124.9 ± 22.2 *#	88.3 ± 9.2 *

Mean (±SEM, n = 6 per sub-population, N = 24) concentration (ng/dg wet tissue) of striatal DA and its metabolites, as a function of immunization group and of the sub-population as emerged in the operant-behaviour task. * p < 0.05 between DAT-i and VEH control group within the corresponding slope-defined sub-population; # p < 0.05 between sub-populations within the same immunization group.

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