Figure 1
From: Extinction learning deficit in a rodent model of attention-deficit hyperactivity disorder
Mean (+/− SEM) response rates during maintenance (M), and extinction sessions (EXT1 and EXT2), in SHR (closed circles) and WKY (open circles), plotted on semi-log coordinates. Mean simulated rates are shown as curves. Maintenance response rates were calculated from the last four sessions prior to extinction, when the VI 192-s schedule was in effect. Response rates were calculated for each eighth of EXT1 and EXT2 (8.125-min bins; mid-points shown on x-axis). Data points for SHR are slightly shifted to the left for visibility. Response rates declined significantly over the course of EXT1 and EXT2 (p < .004). Response rates were significantly higher for SHR than WKY, but only in EXT1 (p = .008). Mean simulated response rates based on fitted DBERM parameters (Tables 1 and 2) closely tracked the observed response rates during EXT1 and EXT2.