Extinction learning deficit in a rodent model of attention-deficit hyperactivity disorder

Table 1 Estimated DBERM parameter medians (95% credible interval) for each strain in EXT1

Parameter	Description	SHR	WKY
Baseline Parameters
L₀	Mean bout length^† (resp)	0.91 (0.31-2.61)	2.81 (1.79 – 4.27)
w₀	Within-bout response rate (min^-1)	253.71 (90.76 – 687.57)	175.68 (99.49 – 307.82)
b₀	Bout-initiation rate (min^-1)	42.74 (27.54 -70.92)*	14.70 (8.76 – 25.14)*
Half-Lives
H_L	Half-life of L (min)	2794.48 (79.50 – 6.9 × 10⁵)*	19.37 (9.35 – 55.72)*
H_w	Half-life of w (min)	42.94 (9.77 – 244.32)	21.28 (5.80 – 104.20)
H_b	Half-life of b (min)	7.77 (4.81 – 12.88)	4.69 (1.58 – 11.26)
Ancillary Parameters
δ	Refractory period (s)	0.11 (0.11 – 0.11)	0.12 (0.10 – 0.15)
Ω	Asymptotic response rate (min^-1)	2.37 (0.81 – 6.76)	1.64 (1.07 – 2.50)

^†Bout length is the number of responses in a bout minus the bout-initiating response. E.g., a bout of length 1 means that 2 responses comprised the bout, whereas a bout length 0.5 means that on average, one within-bout response occurs for every two bout-initiation responses. This arrangement is designed to allow bout length to decline to zero over extinction, as indicated in Equation 3.
*Significant difference between strains (95% credible interval of differences between strains did not envelop zero).

ISSN: 1744-9081