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Table 2 Regional changes in activation in the MDD/GADgroup relative to a non-depressed control group.

From: Generalized anxiety modulates frontal and limbic activation in major depression

Task Increased activation     Decreased activation    
Sentences Region Voxels Talairach Z Region Voxels Talairach Z
Angry L Culmen 40 -16 -51 -18 3.44 L Caudate 133 -12 2 11 4.3
  L Parahippocampus 63 -26 -32 -15 3.33 R Medial Frontal 58 24 32 15 3.53
  L Insula 52 -34 -22 20 3.29 R Anterior Cingulate - 22 39 7 2.98
  L Superior Temporal - -38 -29 12 2.52 L Medial Frontal 57 -22 25 30 3.35
  L Claustrum 25 -22 23 -1 3.13 LCculmen 39 -2 -41 -3 3.13
  L Inferior Parietal 29 -46 -32 -24 2.87 L Thalamus - -2 -29 7 2.91
      R Middle Frontal 31 24 27 30 2.93
      L Cingulate 27 -4 23 39 2.67
Happy L Amygdala 29 -32 -4 -12 3.34 L Anterior Cingulate 32 -22 35 9 4.15
  L Lingual gyrus 26 -12 -70 3 3.24 R Middle Frontal ** 163 24 27 32 3.87
  R Precuneus 59 20 -67 24 3.2 R Anterior Cingulate - 24 30 19 2.99
  R Posterior Cingulate - 26 -61 20 2.94 L Cingulate 48 -16 6 46 3.72
  R Middle Temporal - 30 -57 23 2.43 L Middle Frontal ** - -24 2 40 2.93
  R Thalamus 35 20 -20 -2 2.83 L Caudate 31 -10 1 13 3.49
  R Putamen - 26 -21 1 2.6 L Inferior Frontal 42 -40 3 27 3.31
  R Culmen 25 6 -35 -2 2.8     
Sad R Superior Temporal 51 42 -27 3 3.53 R Anterior Cingulate 80 22 32 9 3.38
      R Claustrum - 24 26 8 3.18
      R Medial Frontal 32 22 27 32 2.99
Faces         
Angry      L Inferior Parietal 84 -38 -31 31 3.95
      R Insula 28 34 -25 9 3.74
      L Middle Frontal ** 41 -30 29 28 3.62
      L Insula** - -34 26 17 2.95
      R Cingulate 54 18 -6 43 3.21
Happy L Posterior Cingulate 82 -10 -44 13 3.71 R Middle Frontal 11 32 13 27 5.57
  L Parahippocampus - -14 46 6 2.82     
  L Inferior Parietal 36 -28 -51 32 3.55     
  R Lingual gyrus 69 4 -80 1 3.34     
  R Cuneus - 12 -83 10 2.51     
  R Posterior Cingulate 33 6 -56 5 3.22     
  R Lingual gyrus 46 14 -70 2 3.1     
  R Cingulate 52 8 -27 36 3.06     
Sad      L Inferior Parietal 83 -40 -31 31 3.95
      R Inferior Parietal 28 34 -31 38 3.74
      R Insula ** 41 -30 25 9 3.62
      L Middle Frontal - -34 29 28 2.95
      L Insula 54 16 26 17 3.21
      R Cingulate - 18 -6 43 2.99
  1. ** Regions showing a positive correlation with anxiety.