Generalized anxiety modulates frontal and limbic activation in major depression

Schlund, Michael W; Verduzco, Guillermo; Cataldo, Michael F; Hoehn-Saric, Rudolf

doi:10.1186/1744-9081-8-8

Behavioral and Brain Functions

Table 2 Regional changes in activation in the MDD/GADgroup relative to a non-depressed control group.

From: Generalized anxiety modulates frontal and limbic activation in major depression

Task	Increased activation				Decreased activation
Sentences	Region	Voxels	Talairach	Z	Region	Voxels	Talairach	Z
Angry	L Culmen	40	-16 -51 -18	3.44	L Caudate	133	-12 2 11	4.3
	L Parahippocampus	63	-26 -32 -15	3.33	R Medial Frontal	58	24 32 15	3.53
	L Insula	52	-34 -22 20	3.29	R Anterior Cingulate	-	22 39 7	2.98
	L Superior Temporal	-	-38 -29 12	2.52	L Medial Frontal	57	-22 25 30	3.35
	L Claustrum	25	-22 23 -1	3.13	LCculmen	39	-2 -41 -3	3.13
	L Inferior Parietal	29	-46 -32 -24	2.87	L Thalamus	-	-2 -29 7	2.91
					R Middle Frontal	31	24 27 30	2.93
					L Cingulate	27	-4 23 39	2.67
Happy	L Amygdala	29	-32 -4 -12	3.34	L Anterior Cingulate	32	-22 35 9	4.15
	L Lingual gyrus	26	-12 -70 3	3.24	R Middle Frontal **	163	24 27 32	3.87
	R Precuneus	59	20 -67 24	3.2	R Anterior Cingulate	-	24 30 19	2.99
	R Posterior Cingulate	-	26 -61 20	2.94	L Cingulate	48	-16 6 46	3.72
	R Middle Temporal	-	30 -57 23	2.43	L Middle Frontal **	-	-24 2 40	2.93
	R Thalamus	35	20 -20 -2	2.83	L Caudate	31	-10 1 13	3.49
	R Putamen	-	26 -21 1	2.6	L Inferior Frontal	42	-40 3 27	3.31
	R Culmen	25	6 -35 -2	2.8
Sad	R Superior Temporal	51	42 -27 3	3.53	R Anterior Cingulate	80	22 32 9	3.38
					R Claustrum	-	24 26 8	3.18
					R Medial Frontal	32	22 27 32	2.99
Faces
Angry					L Inferior Parietal	84	-38 -31 31	3.95
					R Insula	28	34 -25 9	3.74
					L Middle Frontal **	41	-30 29 28	3.62
					L Insula**	-	-34 26 17	2.95
					R Cingulate	54	18 -6 43	3.21
Happy	L Posterior Cingulate	82	-10 -44 13	3.71	R Middle Frontal	11	32 13 27	5.57
	L Parahippocampus	-	-14 46 6	2.82
	L Inferior Parietal	36	-28 -51 32	3.55
	R Lingual gyrus	69	4 -80 1	3.34
	R Cuneus	-	12 -83 10	2.51
	R Posterior Cingulate	33	6 -56 5	3.22
	R Lingual gyrus	46	14 -70 2	3.1
	R Cingulate	52	8 -27 36	3.06
Sad					L Inferior Parietal	83	-40 -31 31	3.95
					R Inferior Parietal	28	34 -31 38	3.74
					R Insula **	41	-30 25 9	3.62
					L Middle Frontal	-	-34 29 28	2.95
					L Insula	54	16 26 17	3.21
					R Cingulate	-	18 -6 43	2.99

** Regions showing a positive correlation with anxiety.

Back to article page

ISSN: 1744-9081

Contact us

Submission enquiries: journalsubmissions@springernature.com