Table 1 MtDNA and 5TTLPR genotypes, clinical symptoms and medication of MT patients
From: Psychiatric symptoms of patients with primary mitochondrial DNA disorders
ID | mtDNA mutation | 5HTTLPR genotype | Symptoms | Medication (with total daily dose) |
|---|---|---|---|---|
1 | A3243G MELAS | L/S | Hypoacusis, ataxia, myopathy, endocrine dysfunction | - |
2 | A3243G MELAS | L/S | Ataxia | - |
3 | A3243G MELAS | L/S | CPEO, myopathy (mother of Patient 4) | - |
4 | A3243G MELAS | L/S | CPEO | - |
5 | A8344G MERRF | L/L | Migraine | - |
6 | A8344G MERRF | S/S | Mild tremor in the upper limbs (mother of Patient 7 and 8) | - |
7 | A8344G MERRF | S/S | Myoclonus epilepsy, thrombocytopenia (twin brother of Patient 8) | levetiracetam (1000 mg), clonazepam (2 mg), valproate (1500 mg), vinpocetine (20 mg) |
8 | A8344G MERRF | S/S | Myoclonus epilepsy, ataxia, cognitive dysfunction, thrombocytopenia (twin brother of Patient 7) | levetiracetam (2500 mg), valproate (2100 mg), vinpocetine (90 mg), trimetazidine (40 mg), betaxolol (10 mg), atorvastatine (10 mg), allopurinol (200 mg) |
9 | T8993G NARP | L/S | Developmental abnormality of the right arm, hypothyreosis, (mother of Patient 10) | - |
10 | T8993G NARP | L/L | NARP | clonazepam ( 1 mg ) vinpocetine ( 10 mg ) |
11 | mtDNA del | L/L | CPEO, iron-deficient anemia, hypercholesterolemia | - |
12 | mtDNA del | L/S | Myalgia, exercise intolerance | sertraline (50 mg) |
13 | mtDNA del | L/S | Kearns-Sayre syndrome | clonazepam ( 1 mg ) vinpocetine ( 20 mg ) mirtazapine ( 30 mg ) |
14 | A 8 3 3 2 G C 8 2 7 0 T | L/S | Dystonia, early onset stroke-like symptoms | levetiracetam ( 1000 mg ) , clonazepam ( 1. 25 mg ) carbamazepine ( 1000 mg ) |
15 | A12770G | L/S | Ataxia, hypoacusis, spastic paraparesis | - |
16 | A15326G A750G A1438G A8860G A15326G | L/L | Hypoacusis, limb tremor, myalgia, apraxia ( mother of Patient 1 7 ) | trimetazidine ( 6 0 mg ), metformin ( 8 5 0 mg), bisoprolol ( 5 mg ), quetiapine ( 4 0 0 mg ), lamotrigine ( 5 0 mg ), trazodone ( 3 0 0 mg ) |
17 | see Patient 16. | L/L | - | - |
18 | A3720G G3849A T13020C T13734C A12308G T8473C | L/S | Severe cardiomyopathy, cognitive dysfunction | trimetazidine (40 mg), enalapril (5 mg), molsidomine (4 mg), quetiapine (400 mg), lamotrigine (100 mg), sertraline (100 mg), clonazepam (1.5 mg) |
19 | C14766T G709A A73G T16126C | S/S | Peripheral neuropathy | tolperisone (300 mg), aceclofenac (200 mg), aripiprazole (15 mg), duloxetine (30 mg), clonazepam (1 mg) |