From: Psychiatric symptoms of patients with primary mitochondrial DNA disorders
ID | PMP22 mutation | 5HTTLPR genotype | Symptoms | Medication (with total daily dose) |
---|---|---|---|---|
20 | PMP22 duplication | L/L | Mild atrophy of the hand and feet muscles | - |
21 | PMP22 duplication | L/L | Pes equinovarus, moderate paresis in the distal muscles of the legs | - |
22 | PMP22 deletion | S/S | Sensory disturbancies in the lower limbs, neuropathy to pressure palsy | - |
23 | PMP22 duplication | S/S | Generalized muscle weakness, walking difficulty, distal type hypesthesia in the limbs, excavated feet | pregabalin (300 mg) duloxetine (30 mg) |
24 | PMP22 duplication | L/S | Paresthesia, distal type hypesthesia in the limbs, muscle cramps, gait instability | - |
25 | PMP22 duplication | L/S | Distal type muscle weakness in the limbs, tremor in the hands | chlordiazepoxide (5 mg) tolperisone (150 mg) propranolol (40 mg) |
26 | PMP22 duplication | L/S | Excavated feet, moderate distal paresis of the limbs, ataxia | - |
27 | PMP22 duplication | S/S | Mild paresis in the hand and feet muscles | - |
28 | PMP22 duplication | S/S | Moderate distal weakness of the limbs, distal type hypesthesia, head tremor, gait instability. Associated disorders: diabetes mellitus, hyperlipidaemia | duloxetine (60 mg) gabapentin (600 mg) rosuvastatine (20 mg) ezetimibe (10 mg) |
29 | PMP22 duplication | L/L | Moderate atrophy and paresis in the hand and feet muscles, gait instability. Associated disorder: asthma bronchiale | - |