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Table 2 The rs2234693-rs9340799 haplotype association analysis

From: Association of estrogen receptor alpha gene polymorphism with age at onset, general psychopathology symptoms, and therapeutic effect of schizophrenia

Group

rs2234693

rs9340799

Frequencies

OR (95% CI)

p-value

Global haplotype association

Cases

Controls

All

All

T

A

0.478

0.620

0.550

1

 

< 0.0001

C

A

0.323

0.187

0.253

0.45 (0.33 - 0.61)

< 0.0001

C

G

0.070

0.191

0.133

1.94 (1.23 - 3.06)

0.0046

T

G

0.130

0.002

0.064

0.01 (0.00 - 0.10)

< 0.0001

Male

T

A

0.473

0.654

0.563

1

 

< 0.0001

C

A

0.294

0.195

0.244

0.47 (0.30 - 0.73)

0.0009

C

G

0.058

0.151

0.105

1.75 (0.83 - 3.69)

0.14

T

G

0.176

0.000

0.088

0.00 (−Inf - Inf)

1

Female

T

A

0.490

0.585

0.540

1

 

< 0.0001

C

A

0.344

0.179

0.259

0.44 (0.28 - 0.68)

0.0002

C

G

0.090

0.232

0.163

2.04 (1.18 - 3.53)

0.012

T

G

0.076

0.004

0.037

0.04 (0.01 - 0.35)

0.0035

  1. Boldface letters represent that the Bonferroni corrected p-values are still less than 0.05.