Association of estrogen receptor alpha gene polymorphism with age at onset, general psychopathology symptoms, and therapeutic effect of schizophrenia

Table 4 Association analysis of rs2234693 with therapeutic effects in 6-week therapy

Group	Characteristic	Codominant		Dominant		Recessive
Group	Characteristic	F/X²	p-value	F/X²	p-value	F/X²	p-value
All	Percentage reduction in general psychopathology score	2.964	0.054	5.259	0.023	0.003	0.955
	Reduction in tension score	1.879	0.155	0.693	0.406	3.718	0.055
	Reduction in poor impulse control score	1.928	0.165	4.153	0.043	10.721	0.001
Male	Percentage reduction in general psychopathology score	0.290	0.749	0.508	0.478	0.246	0.621
	Reduction in tension score	1.482	0.233	0.599	0.441	2.938	0.090
	Reduction in poor impulse control score	0.157	0.692	0.330	0.567	6.657	0.012
Female	Percentage reduction in general psychopathology score	3.784	0.026	6.168	0.015	0.123	0.727
	Reduction in tension score	0.562	0.572	0.148	0.701	1.129	0.290
	Reduction in poor impulse control score	3.946	0.022	5.604	0.020	4.514	0.036
Paranoid	Percentage reduction in general psychopathology score	3.264	0.041	6.567	0.011	0.636	0.426
	Reduction in tension score	2.339	0.100	0.223	0.637	4.670	0.032
	Reduction in poor impulse control score	1.163	0.281	3.442	0.065	10.756	0.001
Aripirazole	Percentage reduction in general psychopathology score	1.321	0.272	2.316	0.132	1.148	0.287
	Reduction in tension score	5.721	0.005	4.920	0.029	9.731	0.002
	Reduction in poor impulse control score	1.019	0.365	0.538	0.465	1.989	0.162
Risperidone	Percentage reduction in general psychopathology score	2.213	0.115	1.797	0.183	1.274	0.262
	Reduction in tension score	0.591	0.555	1.136	0.289	0.295	0.588
	Reduction in poor impulse control score	6.632	0.002	6.035	0.016	10.423	0.002

Boldface letters represent that the Bonferroni corrected p-values are still less than 0.05.

ISSN: 1744-9081