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Figure 1 | Behavioral and Brain Functions

Figure 1

From: The role of autophagy in Parkinson's disease: rotenone-based modeling

Figure 1

Rotenone dose- and time-dependently induced cytotoxicity in SH-SY5Y. The MTT assay was employed to assess the cell viability after rotenone administration. For dose-dependence, rotenone was given at a concentration of 0.1, 0.5, 1, 2.5, 5, 10 and 20 μM for 24 hours. For time-dependence, rotenone (2.5μM) was given for 3, 6, 12, 24, 36 and 48 hours respectively to induce cell damage. (A) Dose-dependent effect of 24-hour treatment with rotenone on cell proliferation in SH-SY5Y (relative MTT value); (B) Time-dependent effect of rotenone (2.5 μM) on SH-SY5Y viability with different experimental time points (from 1–48 hours after rotenone administration; *P < 0.05, compared to Con-group).

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