Figure 6

Rotenone-induced ultrastructural changes in SNc of parkinsonian rats. A: normal mitochondria, Golgi complex and ribosomes in the contralateral SNc of the parkinsonian animals; B and C: mitochondrial swelling, mitochondrial crest fracture, mitochondrial vacuolar degeneration, dilated and broken rough endoplasmic reticula, increase in autophagic vacuoles and increase in lysosome density in lesioned SNc of the parkinsonian animals one or two days after surgery; D: normal medullary sheathes in the contralateral SNc of the parkinsonian animals; E, F and G: mitochondrial swelling, mitochondrial crest fracture, mitochondrial vacuolar degeneration, dilated and broken rough endoplasmic reticula, lipofuscin deposition, perinuclear space augmentation and/or increase in autophagic vacuoles in lesioned SNc of the parkinsonian animals one, two or four weeks after surgery; H: degeneration of the medullary sheathes in lesioned SNc of the parkinsonian animals four weeks after surgery; I: quantitative analysis of autophagic vacuoles/unit area in SNc neurons (see Table 1 for frequency of occurrence of these ultrastructural changes at various time points; *P < 0.05, compared to Con-group).