Figure 3From: Alleviation of chronic neuropathic pain by environmental enrichment in mice well after the establishment of chronic painEffect of environmental manipulation on spinal SP and CGRP content in neuropathic and sham control mice. Substance P (A) and CGRP (B) concentrations were lower in the enriched vs. impoverished neuropathic animals, but no significant difference in peptides concentrations was seen in control mice. Since the 2-way ANOVA revealed an environmental effect but no interaction between environment (enriched vs. impoverished) x time, the data was analyzed by unpaired t-test, enriched vs. impoverished, within pathological condition (neuropathic vs. sham). * p < 0.05, ** p < 0.01, mean ± SEM, n = 7/group.Back to article page