Effects of ω-3 supplementation on stress markers. (A) Restraint stress decreased the % of entries into the open arms of both control and vehicle group rats (p < 0.05). Supplementation with ω-3 increased the % of entries into the open arms among the stressed rats compared to unstressed animals (p < 0.05), producing an anxiolytic effect. (B) After acute swim, restraint stress significantly increased plasma corticosterone levels, but supplementation with ω-3 prevented this alteration. Error bars indicate the means ± SEM. An asterisk (*) indicates significant differences.