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Table 2 Association between PAH polymorphisms and indices of the WMS-R

From: Possible association between common variants of the phenylalanine hydroxylase (PAH) gene and memory performance in healthy adults

WMS-R Index Mean ± S.D. SNP of PAH gene
rs1722387 rs3817446 rs1718301 rs2037639 rs10860936 rs11111419
Genotype   A/A A/G G/G A/A A/G G/G A/A A/G G/G A/A A/G G/G C/C C/T T/T A/A A/T T/T
Verbal memory 110.7 ± 14.0 104.6 109.6 111.2 104.8 111.9 111.0 113.5 110.1 110.9 112.0 111.3 106.0 104.8 108.9 111.4 111.6 110.5 103.9
F = 3.57, p =0.029 F = 3.8, p =0.023 F = 2.1, p =0.12 F = 6.7, p =0.0013 F = 5.5, p =0.0042 F = 5.0, p =0.0067
Visual memory 107.6 ± 11.2 106.4 107.9 107.6 107.1 108.2 107.3 110.0 108.1 107.5 107.5 108.3 107.0 107.5 107.7 107.7 107.9 107.0 109.1
F = 0.26, p =0.77 F = 0.041, p =0.96 F = 0.80, p =0.45 F = 0.13, p =0.88 F = 0.33, p =0.72 F = 1.4, p =0.26
General memory 111.3 ± 12.8 105.8 111.3 111.5 107.0 112.7 111.2 114.5 110.9 111.5 112.0 112.1 108.1 106.2 110.8 111.7 111.9 111.2 107.4
F = 0.89, p =0.41 F = 1.9, p =0.15 F = 2.4, p =0.089 F = 2.8, p =0.060 F = 1.5, p =0.22 F = 1.4, p =0.26
Attention/Concentration 106.3 ± 13.4 104.1 106.9 106.2 106.0 106.8 106.2 103.2 106.8 106.1 107.0 106.0 105.6 107.1 106.0 106.5 106.1 107.3 105.8
F = 0.47, p = 0.62 F = 0.18, p =0.83 F = 0.14, p =0.87 F = 1.1, p =0.35 F = 0.48, p =0.62 F = 0.79, p =0.45
Delayed recall 110.3 ± 12.7 105.8 111.1 110.3 107.9 111.8 110.1 112.4 109.7 110.7 110.7 111.0 108.7 109.5 110.3 110.6 111.0 110.0 109.0
F = 0.38, p =0.69 F = 0.48, p =0.62 F = 1.3, p =0.27 F = 0.44, p =0.65 F = 0.87, p =0.42 F = 0.71, p =0.49
  1. P values of co-dominant model of ANCOVA controlling for education years and sex are shown. P values in boldface and underlined mean nominally significant (p < 0.05) and significant for Bonferroni correction for 30 tests (p < 0.0017 =0.05/30), respectively.