Skip to main content

Table 2 Association between PAH polymorphisms and indices of the WMS-R

From: Possible association between common variants of the phenylalanine hydroxylase (PAH) gene and memory performance in healthy adults

WMS-R Index

Mean ± S.D.

SNP of PAH gene

rs1722387

rs3817446

rs1718301

rs2037639

rs10860936

rs11111419

Genotype

 

A/A

A/G

G/G

A/A

A/G

G/G

A/A

A/G

G/G

A/A

A/G

G/G

C/C

C/T

T/T

A/A

A/T

T/T

Verbal memory

110.7 ± 14.0

104.6

109.6

111.2

104.8

111.9

111.0

113.5

110.1

110.9

112.0

111.3

106.0

104.8

108.9

111.4

111.6

110.5

103.9

F = 3.57, p =0.029

F = 3.8, p =0.023

F = 2.1, p =0.12

F = 6.7, p =0.0013

F = 5.5, p =0.0042

F = 5.0, p =0.0067

Visual memory

107.6 ± 11.2

106.4

107.9

107.6

107.1

108.2

107.3

110.0

108.1

107.5

107.5

108.3

107.0

107.5

107.7

107.7

107.9

107.0

109.1

F = 0.26, p =0.77

F = 0.041, p =0.96

F = 0.80, p =0.45

F = 0.13, p =0.88

F = 0.33, p =0.72

F = 1.4, p =0.26

General memory

111.3 ± 12.8

105.8

111.3

111.5

107.0

112.7

111.2

114.5

110.9

111.5

112.0

112.1

108.1

106.2

110.8

111.7

111.9

111.2

107.4

F = 0.89, p =0.41

F = 1.9, p =0.15

F = 2.4, p =0.089

F = 2.8, p =0.060

F = 1.5, p =0.22

F = 1.4, p =0.26

Attention/Concentration

106.3 ± 13.4

104.1

106.9

106.2

106.0

106.8

106.2

103.2

106.8

106.1

107.0

106.0

105.6

107.1

106.0

106.5

106.1

107.3

105.8

F = 0.47, p = 0.62

F = 0.18, p =0.83

F = 0.14, p =0.87

F = 1.1, p =0.35

F = 0.48, p =0.62

F = 0.79, p =0.45

Delayed recall

110.3 ± 12.7

105.8

111.1

110.3

107.9

111.8

110.1

112.4

109.7

110.7

110.7

111.0

108.7

109.5

110.3

110.6

111.0

110.0

109.0

F = 0.38, p =0.69

F = 0.48, p =0.62

F = 1.3, p =0.27

F = 0.44, p =0.65

F = 0.87, p =0.42

F = 0.71, p =0.49

  1. P values of co-dominant model of ANCOVA controlling for education years and sex are shown. P values in boldface and underlined mean nominally significant (p < 0.05) and significant for Bonferroni correction for 30 tests (p < 0.0017 =0.05/30), respectively.