Pharmacotherapy response and regional cerebral blood flow characteristics in patients with obsessive-compulsive disorder

Table 3 The coordinates and Z scores of abnormal rCBF in SSRI plus quetiapine group and normal controls before treatment

Hemisphere	Brain region	Coordinates(mm)^a			Z scores^b	P value
Hemisphere	Brain region	X	Y	Z	Z scores^b	P value
Decreased rCBF
left	inferior parietal lobule	−42	−52	46	6.98	0.000
left	Vermis cerebelli	−6	−74	−32	6.91	0.000
right	Occiput wedge leaf	6	−70	16	7.06	0.000
Increased rCBF
left	Tonsil of cerebellum	−34	−58	−38	5.09	0.000
left	Globus pallidus	−22	−12	4	4.75	0.000
right	Thalamus lateral nucleus	22	−18	8	4.61	0.000
right	Lentiform nucleus	30	−20	8	6.67	0.000
right	Middle frontal gyrus	12	52	16	4.41	0.000

^a Coordinates from the stereotaxic atlas of Talairach and Tournoux.
^b Peak activation in a cluster of at least 50 voxels in which the difference survived a threshold of P < 0.001 in a random-effects analysis.

ISSN: 1744-9081