Figure 3

Effects of oral administration of increasing doses of biperiden on working memory (A) and reference memory performance (B), trial duration (C), and latency to first rewarded hole visit (D) of conventional pigs and Göttingen minipigs. The means + SEM of the drug-free day preceding treatment and of the day of biperiden treatment are depicted. None of the conventional pigs consumed the entire 20 mg.kg^-1 dose. Consequently, these data were not analyzed, and only the data of the Göttingen minipigs are shown for the highest dose of Biperiden.