Performance of conventional pigs and Göttingen miniature pigs in a spatial holeboard task: effects of the putative muscarinic cognition impairer Biperiden

Table 1 Biperiden effects per pig line and dose of Biperiden

Biperiden (mg.kg^-1body mass, p.o.)	Conventional pigs		Göttingen minipigs		Conventional pigs		Göttingen minipigs
	Working memory				Reference memory
0.05	t₈ = 0.36	p = 0.7318	t₈ = 2.05	p = 0.0796	t₈ = 1.18	p = 0.2765	t₈ = 0.34	p = 0.7425
0.15	t₈ = -0.24	p = 0.8157	t₈ = 1.63	p = 0.1477	t₈ = 0.09	p = 0.9332	t₈ = -0.66	p = 0.5277
1.5	t₈ = 0.39	p = 0.7055	t₈ = 0.55	p = 0.5983	t₈ = -1.43	p = 0.1966	t₈ = 0.27	p = 0.7986
5	t₈ = 0.14	p = 0.8916	t₈ = -0.62	p = 0.5577	t₈ = -2.96	*p = 0.0212*	t₈ = -4.75	*p = 0.0021*
15	t₇ = -0.46	p = 0.6585	t₈ = -0.41	p = 0.6975	t₇ = -2.41	p = 0.0528	t₈ = -0.22	p = 0.8316
20	n.t.		t₈ = -2.50	*p = 0.0412*	n.t.		t₈ = -3.55	*p = 0.0094*
	Trial duration				Latency to first rewarded hole visit
0.05	t₈ = -0.81	p = 0.4427	t₈ = -1.31	p = 0.2325	t₈ = -1.00	p = 0.3519	t₈ = -1.25	p = 0.2522
0.15	t₈ = 0.89	p = 0.4032	t₈ = -1.45	p = 0.1895	t₈ = 0.08	p = 0.9375	t₈ = 0.29	p = 0.7797
1.5	t₈ = -0.49	p = 0.6358	t₈ = -0.78	p = 0.4612	t₈ = -1.18	p = 0.2749	t₈ = -0.74	p = 0.4831
5	t₈ = 4.27	*p = 0.0037*	t₈ = 0.21	p = 0.8401	t₈ = -1.63	p = 0.1476	t₈ = -1.98	p = 0.0876
15	t₇ = 1.55	p = 0.1725	t₈ = 2.05	p = 0.0792	t₇ = -3.00	*p = 0.0241*	t₈ = -1.57	p = 0.1614
20	n.t.		t₈ = 1.98	p = 0.088 7	n.t.		t₈ = -5.11	*p = 0.0014*

One-sample t-statistics and the associated p-values of the difference scores between the control sessions preceding treatment and the corresponding treatment sessions are tabulated. Abbreviation: n.t. not tested, because none of the conventional pigs consumed the entire dose of 20 mg.kg^-1. p-values < 0.05 are printed bold and italicized, p-values between 0.05 and 0.1 (marginal effects) are italicized.

ISSN: 1744-9081