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Table 2 Effects of the CNNM2 genotype and genotype-diagnosis interaction on GM volumes

From: The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia

Brain regions

R/L

BA

CS

p values (peak)

Talairach coordinates

    

T

FWE

x

y

z

Non-risk minor allele carrier > Risk major allele homozygote

Inferior frontal Gyrus

R

11/47

1306

4.96

0.0088

22

31

-20

Inferior frontal Gyrus

L

47

437

4.66

0.031

-22

18

-22

Middle frontal Gyrus

L

11

667

4.33

0.11

-24

38

-18

Posterior cingulate

L

29

248

3.73

0.61

-7

-48

11

Non-risk minor allele carrier < Risk major allele homozygote

no suprathreshold clusters

        

Genotype-diagnosis interaction

Superior temporal Gyrus

L

22

598

4.23

0.16

-46

-20

1

  1. Abbreviations: R right; L left; BA Brodmann area; CS Cluster size; FWE family-wise error.
  2. All regions shown have nominal association at a voxel-level height threshold of uncorrectedp < 0.001 and a minimum clusters extent of 100 voxels. Significant results (FWE-correctedp < 0.05) are shown in bold face.