Figure 1
From: Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats
The effect of MPEP on the locomotion of ethanol withdrawn rats. The effect of MPEP (2.5, 5, 10, 20, and 30 mg/kg) on basic and fine movement (A), X and Y ambulation (B) in the automated elevated plus maze of ethanol withdrawn rats after 7 hours of withdrawal. Each column represents the mean ± S.E.M [n = 8 for each group; EN = Control rats fed MLD without ethanol and treated with saline; EW = Ethanol Withdrawal (the ethanol withdrawn group treated with normal saline); EW + 2.5, EW + 5,EW + 10, EW + 20, EW + 30 MPEP = ethanol withdrawn group treated with respective doses of MPEP (mg/kg); **p < 0.01,***p < 0.001 vs EN; #p < 0.05 vs EW; αp < 0.05, ααp < 0.001 vs 2.5 mg/kg MPEP; βp < 0.05 vs 5 mg/kg MPEP, One Way Analysis of Variance and post hoc Tukey’s test].