Figure 2

The effect of MPEP on open and closed arm behaviours. The effect of MPEP (2.5, 5, 10, 20, and 30 mg/kg) on percent total time spent in the open arms (A), and the open and closed arm entries (B) of the automated elevated plus maze of ethanol withdrawn rats 7 hours after withdrawal. Each column represents the mean ± S.E.M [n = 8 for each group; EN = Control rats fed MLD without ethanol and treated with saline; EW = Ethanol Withdrawal (ethanol withdrawn group treated with normal saline); EW + 2.5, EW + 5,EW + 10, EW + 20, EW + 30 MPEP = ethanol withdrawn group treated with respective doses of MPEP (mg/kg);*p < 0.05,**P < 0.01, ***p < 0.001 vs EN; #p < 0.05, ##p < 0.01,###p < 0.001 vs EW; αp < 0.05, αααp < 0.001 vs 2.5 mg/kg MPEP; βββp < 0.001 vs 5 mg/kg MPEP; μμμp < 0.001 vs 20 mg/kg MPEP; $$p < 0.01 vs 30 mg/kg MPEP,One Way Analysis of Variance and post hoc Tukey’s test].