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Figure 4 | Behavioral and Brain Functions

Figure 4

From: Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats

Figure 4

The effect of MPEP on open field behaviours. The effect of MPEP (2.5, 5, 10, 20, and 30 mg/kg) on the percent total time (A) and the entries (B) produced in the central zone of the open field by ethanol withdrawn rats 7 hours after withdrawal. Each column represents the mean ± S.E.M [n = 8 for each group; EN = Control rats fed MLD without ethanol and treated with saline; EW = Ethanol Withdrawal (ethanol withdrawn group treated with normal saline); EW + 2.5, EW + 5,EW + 10, EW + 20, EW + 30MPEP = ethanol withdrawn group treated with respective doses of MPEP (mg/kg); *p < 0.05, ***p < 0.001 vs EN; #p < 0.05, ###p < 0.001 vs EW, One Way Analysis of Variance and post hoc Tukey’s test].

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