The female but not male rats with IAA-induced gastritis develop anxiety-like behavior. (A) Female rats with IAA-induced gastritis spend less time and travel less distance in the central zone of open field test (OFT). (B) Female rats with IAA-induced gastritis spend less time and travel less distance in the open arms of elevated plus maze (EPM). The OFT and EPM evaluated the anxiety-like behavior. The percentages of the number of entries into, the time spent and the distance traveled in the center zone of OFT and in the open arm of EPM correlated negatively with the anxiety state. IAA, iodoacetamide. Values are means ± S.E.M. *p < 0.05 was significantly different from control group of the same gender. +p < 0.05 was significantly different from male control group. N = 8 rats/male group, N = 6 rats/female group.