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Figure 4 | Behavioral and Brain Functions

Figure 4

From: Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats

Figure 4

The IAA treatment induces hyperactivity of HPA axis in female but not male rats. (A) Crf mRNA expression in hypothalamus is increased in female rats with IAA-induced gastritis. (B) Gr mRNA expression in hypothalamus is reduced in female rats with IAA-induced gastritis. (C) Plasma levels of CORT are decreased in female rats with IAA-induced gastritis. The hypothalamic expressions of corticotropin-releasing factor (CRF) and glucocorticoid receptor (GR), and plasma levels of corticosterone (CORT) were used to assess the HPA axis activity. IAA, iodoacetamide. Values are means ± S.E.M of six rats. *p < 0.05 was significantly different from control group of the same gender. +p < 0.05 was significantly different from male control group.

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