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Table 2 Genotype and Allele frequencies of TPH2 gene polymorphisms between children with TD and normal controls

From: Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population

Polymorphisms Number and frequency (%) χ 2 P a OR [95% CI]
  Normal controls TD children    
TPH2 rs4565946 125 149    
CC 65 (52.00) 78 (52.35)    1.00
CT 53 (42.40) 48 (32.21)` 1.168 0.28 0.755 [0.453–1.258]
TT 7 (5.60) 23 (15.44) 4.994 0.025 2.738 [1.105–6.788]
CC + CT 118 (94.40) 126 (84.56)    1.00
TT 7 (5.60) 23 (15.44) 6.745 0.009 3.077 [1.273–7.437]
C 183 (73.20) 204 (68.46)    1.00
T 67 (26.80) 94 (31.54) 1.474 0.225 1.259 [0.868–1.825]
TPH2 rs4570625 125 149    
TT 44 (35.20) 37 (24.83)    1.00
GT 57 (45.60) 75 (50.34) 2.498 0.114 1.565 [0.897–2.730]
GG 24 (19.20) 37 (24.83) 3.127 0.077 1.833 [0.934–3.599]
TT + GT 101 (80.80) 112 (75.17)    1.00
GG 24 (19.20) 37 (24.83) 1.246 0.264 1.390 [0.779–2.483]
T 145 (58.00) 149 (50.00)    1.00
G 105 (42.00) 149 (50.00) 3.499 0.061 1.381 [0.984–1.937]
  1. Abbreviations: TPH2 = tryptophan hydroxylase2.
  2. a Chi-square test was used to calculate the p-values.