Table 3 Genotype and allele frequencies of TPH2 gene polymorphisms between children with TD and normal controls in the male subgroup
Polymorphisms | Number and frequency (%) | χ 2 | P a | OR [95% CI] | |
|---|---|---|---|---|---|
Male normal controls | Male TD children | ||||
TPH2 rs4565946 | 84 | 112 | |||
CC | 46 (54.76) | 58 (51.79) | |||
CT | 33 (39.29) | 35 (31.25) | 0.306 | 0.580 | 0.841 [0.456–1.553] |
TT | 5 (5.95) | 19 (16.96) | 4.454 | 0.035 | 3.014 [1.046–8.685] |
CC + CT | 79 (94.05) | 93 (83.04) | |||
TT | 5 (5.95) | 19 (16.96) | 5.417 | 0.020 | 3.228 [1.153–9.040] |
C | 125 (74.40) | 151 (67.41) | |||
T | 43 (25.60) | 73 (32.59) | 2.254 | 0.133 | 1.405 [0.900–2.193] |
TPH2 rs4570625 | 84 | 112 | |||
TT | 29 (34.52) | 29 (25.89) | |||
GT | 40 (47.62) | 50 (44.64) | 0.437 | 0.508 | 1.250 [0.645–2.423] |
GG | 15 (17.86) | 33 (29.46) | 3.803 | 0.051 | 2.200 [0.990–4.888] |
TT + GT | 69 (82.14) | 79 (70.54) | |||
GG | 15 (17.86) | 33 (29.46) | 3.497 | 0.061 | 1.922 [0.963–3.833] |
T | 98 (58.33) | 108 (48.21) | |||
G | 70 (41.67) | 116 (51.79) | 3.942 | 0.047 | 1.504 [1.005- 2.251] |