Skip to main content

Advertisement

Table 3 Genotype and allele frequencies of TPH2 gene polymorphisms between children with TD and normal controls in the male subgroup

From: Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population

Polymorphisms Number and frequency (%) χ 2 P a OR [95% CI]
  Male normal controls Male TD children    
TPH2 rs4565946 84 112    
CC 46 (54.76) 58 (51.79)    
CT 33 (39.29) 35 (31.25) 0.306 0.580 0.841 [0.456–1.553]
TT 5 (5.95) 19 (16.96) 4.454 0.035 3.014 [1.046–8.685]
CC + CT 79 (94.05) 93 (83.04)    
TT 5 (5.95) 19 (16.96) 5.417 0.020 3.228 [1.153–9.040]
C 125 (74.40) 151 (67.41)    
T 43 (25.60) 73 (32.59) 2.254 0.133 1.405 [0.900–2.193]
TPH2 rs4570625 84 112    
TT 29 (34.52) 29 (25.89)    
GT 40 (47.62) 50 (44.64) 0.437 0.508 1.250 [0.645–2.423]
GG 15 (17.86) 33 (29.46) 3.803 0.051 2.200 [0.990–4.888]
TT + GT 69 (82.14) 79 (70.54)    
GG 15 (17.86) 33 (29.46) 3.497 0.061 1.922 [0.963–3.833]
T 98 (58.33) 108 (48.21)    
G 70 (41.67) 116 (51.79) 3.942 0.047 1.504 [1.005- 2.251]
  1. Abbreviations: TPH2, tryptophan hydroxylase2.
  2. aChi-square test was used to calculate the p- values.