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Table 4 Allelic and genotypic association analyses of TPH2 polymorphisms in low score subgroup and high score subgroup versus normal controls among the male children

From: Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population

Polymorphisms Number and frequency (%)
  Male normal controls Low score subgroup High score subgroup
rs4565946 84 25 87
CC 46 (54.76) 15 (60.00) 43 (49.43)
CT 33 (39.29) 6 (24.00) 29 (33.33)
TT 5 (5.95) 4 (16.00) 15 (17.24)
χ 2   3.708 5.308
P a   0.157 0.070
CC + CT 79 (94.05) 21 (84.00) 72 (82.76)
TT 5 (5.95) 4 (16.00) 15 (17.24
χ 2   2.568 5.273
P b   0.206 0.022
OR [95%CI]   3.010 [0.742–12.205] 3.292 [1.139–9.513]
C 125 (74.40) 36 (72.00) 115 (66.09)
T 43 (25.60) 14 (28.00) 59 (33.91)
χ 2   0.115 2.822
P b   0.734 0.093
OR [95%CI]   1.130 [0.557–2.295] 1.491 [0.934–2.380]
rs4570625 84 25 87
TT 29 (34.52) 10 (40.00) 19 (21.84)
GT 40 (47.62) 9 (36.00) 41 (47.13)
GG 15 (17.86) 6 (24.00) 27 (31.03)
χ 2   1.117 5.473
P a   0.572 0.065
TT + GT 69 (82.14) 19 (76.00) 60 (68.97)
GG 15 (17.86) 6 (24.00) 27 (31.03)
χ 2   0.467 4.005
P b   0.494 0.045
OR [95%CI]   1.453 [0.496–4.253] 2.070 [1.008–4.252]
T 98 (58.33) 29 (58.00) 79 (45.40)
G 70 (41.67) 21 (42.00) 95 (54.60)
χ 2   0.002 5.724
P b   0.967 0.017
OR [95%CI]   1.014 [0.535–1.922] 1.684 [1.097–2.583]
  1. a Pearson chi square test was used to calculate the p-values.
  2. bChi-square test was used to calculate the p-values. Fisher exact test was used when the sample size was <5.