Advertisement
Table 4 Allelic and genotypic association analyses of TPH2 polymorphisms in low score subgroup and high score subgroup versus normal controls among the male children
| Polymorphisms | Number and frequency (%) | ||
|---|---|---|---|
| Male normal controls | Low score subgroup | High score subgroup | |
| rs4565946 | 84 | 25 | 87 |
| CC | 46 (54.76) | 15 (60.00) | 43 (49.43) |
| CT | 33 (39.29) | 6 (24.00) | 29 (33.33) |
| TT | 5 (5.95) | 4 (16.00) | 15 (17.24) |
| χ 2 | 3.708 | 5.308 | |
| P a | 0.157 | 0.070 | |
| CC + CT | 79 (94.05) | 21 (84.00) | 72 (82.76) |
| TT | 5 (5.95) | 4 (16.00) | 15 (17.24 |
| χ 2 | 2.568 | 5.273 | |
| P b | 0.206 | 0.022 | |
| OR [95%CI] | 3.010 [0.742–12.205] | 3.292 [1.139–9.513] | |
| C | 125 (74.40) | 36 (72.00) | 115 (66.09) |
| T | 43 (25.60) | 14 (28.00) | 59 (33.91) |
| χ 2 | 0.115 | 2.822 | |
| P b | 0.734 | 0.093 | |
| OR [95%CI] | 1.130 [0.557–2.295] | 1.491 [0.934–2.380] | |
| rs4570625 | 84 | 25 | 87 |
| TT | 29 (34.52) | 10 (40.00) | 19 (21.84) |
| GT | 40 (47.62) | 9 (36.00) | 41 (47.13) |
| GG | 15 (17.86) | 6 (24.00) | 27 (31.03) |
| χ 2 | 1.117 | 5.473 | |
| P a | 0.572 | 0.065 | |
| TT + GT | 69 (82.14) | 19 (76.00) | 60 (68.97) |
| GG | 15 (17.86) | 6 (24.00) | 27 (31.03) |
| χ 2 | 0.467 | 4.005 | |
| P b | 0.494 | 0.045 | |
| OR [95%CI] | 1.453 [0.496–4.253] | 2.070 [1.008–4.252] | |
| T | 98 (58.33) | 29 (58.00) | 79 (45.40) |
| G | 70 (41.67) | 21 (42.00) | 95 (54.60) |
| χ 2 | 0.002 | 5.724 | |
| P b | 0.967 | 0.017 | |
| OR [95%CI] | 1.014 [0.535–1.922] | 1.684 [1.097–2.583] | |
