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Table 4 Allelic and genotypic association analyses of TPH2 polymorphisms in low score subgroup and high score subgroup versus normal controls among the male children

From: Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population

Polymorphisms

Number and frequency (%)

 

Male normal controls

Low score subgroup

High score subgroup

rs4565946

84

25

87

CC

46 (54.76)

15 (60.00)

43 (49.43)

CT

33 (39.29)

6 (24.00)

29 (33.33)

TT

5 (5.95)

4 (16.00)

15 (17.24)

χ 2

 

3.708

5.308

P a

 

0.157

0.070

CC + CT

79 (94.05)

21 (84.00)

72 (82.76)

TT

5 (5.95)

4 (16.00)

15 (17.24

χ 2

 

2.568

5.273

P b

 

0.206

0.022

OR [95%CI]

 

3.010 [0.742–12.205]

3.292 [1.139–9.513]

C

125 (74.40)

36 (72.00)

115 (66.09)

T

43 (25.60)

14 (28.00)

59 (33.91)

χ 2

 

0.115

2.822

P b

 

0.734

0.093

OR [95%CI]

 

1.130 [0.557–2.295]

1.491 [0.934–2.380]

rs4570625

84

25

87

TT

29 (34.52)

10 (40.00)

19 (21.84)

GT

40 (47.62)

9 (36.00)

41 (47.13)

GG

15 (17.86)

6 (24.00)

27 (31.03)

χ 2

 

1.117

5.473

P a

 

0.572

0.065

TT + GT

69 (82.14)

19 (76.00)

60 (68.97)

GG

15 (17.86)

6 (24.00)

27 (31.03)

χ 2

 

0.467

4.005

P b

 

0.494

0.045

OR [95%CI]

 

1.453 [0.496–4.253]

2.070 [1.008–4.252]

T

98 (58.33)

29 (58.00)

79 (45.40)

G

70 (41.67)

21 (42.00)

95 (54.60)

χ 2

 

0.002

5.724

P b

 

0.967

0.017

OR [95%CI]

 

1.014 [0.535–1.922]

1.684 [1.097–2.583]

  1. a Pearson chi square test was used to calculate the p-values.
  2. bChi-square test was used to calculate the p-values. Fisher exact test was used when the sample size was <5.
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Behavioral and Brain Functions

ISSN: 1744-9081

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