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Table 2 Genotype frequencies of CTXN3 and DISC1 gene polymorphisms among cases and controls

From: Association between 5q23.2-located polymorphism of CTXN3 gene (Cortexin 3) and schizophrenia in European-Caucasian males; implications for the aetiology of schizophrenia

Genes SNP Genotype Controls ( N = 184) Patiens ( N = 175) OR (95% CI) P value
Number (%) Number (%)
CTXN3 rs6595788 AA 106 57.6 70 40.2 1.00 - -
   AG 67 36.4 86 49.4 1.94 (1.52-3.02) 0.003
   GG 11 6.0 18 10.4 2.48 (1.10-5.65) 0.025
   AG+GG 78 42.4 104 59.8 2.02 (1.33-3.08) 0.001
DISC1 rs17817356 GG 74 40.2 50 28.9 1.00 - -
   AG 80 43.5 99 57.2 1.83 (1.15-2.91) 0.010
   AA 30 16.3 24 13.9 1.18 (0.62-2.26) 0.609
   AG+AA 110 59.8 123 71.1 1.65 (1.06-2.57) 0.025
DISC1 rs821597 GG 74 40.2 70 40.2 1.00 - -
   AG 89 48.4 78 44.8 0.93 (0.59-1.45) 0.737
   AA 21 11.4 26 15.0 1.31 (0.68-2.54) 0.424
   AG+AA 110 59.8 104 59.8 1.00 (0.66-1.53) 0.998
DISC1 rs980989 CC 123 66.9 108 62.1 1.00 - -
   AC 53 28.8 59 33.9 1.27 (0.81-1.99) 0.303
   AA 8 4.3 7 4.0 1.00 (0.35-2.84) 0.995
   AC+AA 61 33.1 66 37.9 1.23 (1.80-1.90) 0.345
DISC1 rs9661837 AA 183 99.5 169 96.6 NC*
   AG 1 0.5 6 3.4
   GG 0 0.0 0 0.0
   AG+GG 1 0.5 6 3.4
DISC1 rs3737597 CC 171 92.9 166 95.4 NC**
   CT 13 7.1 7 4.0
   TT 0 0 1 0.6
   CT + TT 13 7.1 8 4.6
  1. All chi-squared tests are two-tailed. Alpha value is adjusted by Bonferroni correction and statistically significant results (P<0.008) are marked bold.
  2. NC – minor allele frequency to low to calculate precise OR and P values.
  3. *the statistical significance of difference in allele frequencies by Fisher’s exact test is p = 0.06.
  4. **the statistical significance of difference in allele frequencies by Fisher’s exact test is p = 0.4.