Table 2 Genotype frequencies of CTXN3 and DISC1 gene polymorphisms among cases and controls
Genes | SNP | Genotype | Controls ( N = 184) | Patiens ( N = 175) | OR | (95% CI) | P value | ||
|---|---|---|---|---|---|---|---|---|---|
Number | (%) | Number | (%) | ||||||
CTXN3 | rs6595788 | AA | 106 | 57.6 | 70 | 40.2 | 1.00 | - | - |
AG | 67 | 36.4 | 86 | 49.4 | 1.94 | (1.52-3.02) | 0.003 | ||
GG | 11 | 6.0 | 18 | 10.4 | 2.48 | (1.10-5.65) | 0.025 | ||
AG+GG | 78 | 42.4 | 104 | 59.8 | 2.02 | (1.33-3.08) | 0.001 | ||
DISC1 | rs17817356 | GG | 74 | 40.2 | 50 | 28.9 | 1.00 | - | - |
AG | 80 | 43.5 | 99 | 57.2 | 1.83 | (1.15-2.91) | 0.010 | ||
AA | 30 | 16.3 | 24 | 13.9 | 1.18 | (0.62-2.26) | 0.609 | ||
AG+AA | 110 | 59.8 | 123 | 71.1 | 1.65 | (1.06-2.57) | 0.025 | ||
DISC1 | rs821597 | GG | 74 | 40.2 | 70 | 40.2 | 1.00 | - | - |
AG | 89 | 48.4 | 78 | 44.8 | 0.93 | (0.59-1.45) | 0.737 | ||
AA | 21 | 11.4 | 26 | 15.0 | 1.31 | (0.68-2.54) | 0.424 | ||
AG+AA | 110 | 59.8 | 104 | 59.8 | 1.00 | (0.66-1.53) | 0.998 | ||
DISC1 | rs980989 | CC | 123 | 66.9 | 108 | 62.1 | 1.00 | - | - |
AC | 53 | 28.8 | 59 | 33.9 | 1.27 | (0.81-1.99) | 0.303 | ||
AA | 8 | 4.3 | 7 | 4.0 | 1.00 | (0.35-2.84) | 0.995 | ||
AC+AA | 61 | 33.1 | 66 | 37.9 | 1.23 | (1.80-1.90) | 0.345 | ||
DISC1 | rs9661837 | AA | 183 | 99.5 | 169 | 96.6 | NC* | ||
AG | 1 | 0.5 | 6 | 3.4 | |||||
GG | 0 | 0.0 | 0 | 0.0 | |||||
AG+GG | 1 | 0.5 | 6 | 3.4 | |||||
DISC1 | rs3737597 | CC | 171 | 92.9 | 166 | 95.4 | NC** | ||
CT | 13 | 7.1 | 7 | 4.0 | |||||
TT | 0 | 0 | 1 | 0.6 | |||||
CT + TT | 13 | 7.1 | 8 | 4.6 | |||||