Figure 2

Effects of the methanolic extract of Piper nigrum fruits (50 and 100 mg/kg) in the elevated plus-maze test on the percentage of the time spent in the open arms (a), the number of open-arm entries (b) and the number of crossing (c) in the Aβ (1–42)-treated rats. Values are means + S.E.M. (n = 10 animals per group). For Turkey’s post hoc analysis - ^#Aβ (1–42) vs. Aβ (1–42) + P50: p < 0.01 and ^##Aβ (1–42) vs. Aβ (1–42) + P100: p < 0.0001 (a), ^#Aβ (1–42) vs. Aβ (1–42) + P50: p < 0.001 (b) and ^##Aβ (1–42) vs. Aβ (1–42) + P100: p < 0.001 (c).