Figure 4

Effects of the methanolic extract of Piper nigrum fruits (50 and 100 mg/kg) on SOD (a), GPX (b) and CAT (c) specific activities, on total content of reduced GSH (d), protein carbonyl (e) and MDA (f) levels in the Aβ (1–42)-treated rats. Values are means + S.E.M. (n = 10 animals per group). For Turkey’s post hoc analysis - ^#Aβ (1–42) vs. Aβ (1–42)+P50: p<0.0001 and ^##Aβ (1–42) vs. Aβ (1–42)+P100: p<0.0001 (a), ^#Aβ (1–42) vs. Aβ (1–42)+P50: p<0.0001 and ^##Aβ (1–42) vs. Aβ (1–42)+P100: p<0.0001 (b), ^#Aβ (1–42) and Aβ (1–42)+P50 groups (p<0.001) and ^##Aβ (1–42) vs. Aβ (1–42)+P100: p<0.0001(c), ^##Aβ (1–42) vs. Aβ (1–42)+P100: p<0.01 (d), ^#Aβ (1–42) vs. Aβ (1–42)+P50: p<0.0001 and ^##Aβ (1–42) vs. Aβ (1–42)+P100: p<0.0001 (e) and ^#Aβ (1–42) vs. Aβ (1–42)+P50: p<0.0001 and ^##Aβ (1–42) vs. Aβ (1–42)+P100: p<0.0001 (f).