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Figure 4 | Behavioral and Brain Functions

Figure 4

From: Anxiolytic and antidepressant profile of the methanolic extract of Piper nigrum fruits in beta-amyloid (1–42) rat model of Alzheimer’s disease

Figure 4

Effects of the methanolic extract of Piper nigrum fruits (50 and 100 mg/kg) on SOD (a), GPX (b) and CAT (c) specific activities, on total content of reduced GSH (d), protein carbonyl (e) and MDA (f) levels in the Aβ (1–42)-treated rats. Values are means + S.E.M. (n = 10 animals per group). For Turkey’s post hoc analysis - #Aβ (1–42) vs. Aβ (1–42)+P50: p<0.0001 and ##Aβ (1–42) vs. Aβ (1–42)+P100: p<0.0001 (a), #Aβ (1–42) vs. Aβ (1–42)+P50: p<0.0001 and ##Aβ (1–42) vs. Aβ (1–42)+P100: p<0.0001 (b), #Aβ (1–42) and Aβ (1–42)+P50 groups (p<0.001) and ##Aβ (1–42) vs. Aβ (1–42)+P100: p<0.0001(c), ##Aβ (1–42) vs. Aβ (1–42)+P100: p<0.01 (d), #Aβ (1–42) vs. Aβ (1–42)+P50: p<0.0001 and ##Aβ (1–42) vs. Aβ (1–42)+P100: p<0.0001 (e) and #Aβ (1–42) vs. Aβ (1–42)+P50: p<0.0001 and ##Aβ (1–42) vs. Aβ (1–42)+P100: p<0.0001 (f).

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