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Table 3 DRD2 and ANKK1 associations with cognitive domains

From: DRD2 and DRD4 genes related to cognitive deficits in HIV-infected adults who abuse alcohol

Chr. Position Gene Variant Minor Allele A/A A/B B/B MAF Domain OR aallele (95 % CI) P value
11 11:113412737 DRD2 rs6277 T 80 118 60 0.23 Cognitive flexibility 1.6 (1.2–2.6) 0.004
11 11:113412737 DRD2 rs6277 T 80 118 60 0.23 Executive function 3.3 (2.0–5.7) 0.001
11 11:113400106 ANKK1 rs1800497 T 102 117 40 0.16 Cognitive flexibility 1.1 (0.7–1.8) 0.71
  1. ORs adjusted for self-reported ethnicity/race, alcohol use severity, viral load, CD4 count, cannabis and cocaine use
  2. MAF minor allele frequency
  3. aOR per allele (ORallele) for the additive model