Fig. 5

HMGB1 mRNA expression on 48 h after 1st SAH and 72 h after 2nd SAH, respectively (rt-PCR). All groups are identical to those shown in the legends of Fig. 4. #, ##, ###P > 0.01; *, **P < 0.01: represent 4OGOMV treatment significantly attenuated HMGB1 mRNA transcription at a late stage of SAH, when compared with the SAH groups