Table 3 Significant results after multiple comparison correction of logistic regression analysis for single markers
From: Attention deficit hyperactivity disorder: genetic association study in a cohort of Spanish children
Gene | Variant | Model | Genotype | Controls N (%) | Cases N (%) | OR (95 % CI) | p value | p value corrected |
|---|---|---|---|---|---|---|---|---|
All population | ||||||||
L/L–L/S | 241 (71.1) | 239 (83.3) | 1 | |||||
SLC6A4 | Promoter VNTR | Recessive | S/S | 98 (28.9) | 48 (16.7) | 0.52 (0.35–0.77) | 0.0009 | 0.0153 |
A/A–G/G | 177 (52.1) | 185 (63.8) | 1 | |||||
LPHN3 | rs2305339 | Overdominant | A/G | 163 (47.9) | 105 (36.2) | 0.57 (0.41–0.79) | 0.0007 | 0.0153 |
Combined subtype | ||||||||
A/A | 174 (51.2) | 65 (37.1) | 1 | |||||
SLC6A2 | rs28386840 | Dominant | A/T–T/T | 166 (48.8) | 110 (62.9) | 1.76 (1.19–2.59) | 0.0041 | 0.0318 |
G/G | 284 (83.4) | 161 (92.5) | 1 | |||||
G/C | 51 (15.1) | 13 (7.5) | 0.40 (0.21–0.77) | 0.0026 | 0.0269 | |||
SLC6A3 | rs11564750 | Log-additive | C/C | 5 (1.5) | 0 (0) | |||
L/L–L/S | 241 (71.1) | 151 (87.3) | 1 | |||||
SLC6A4 | Promoter VNTR | Recessive | S/S | 98 (28.9) | 22 (12.7) | 0.37 (0.22–0.62) | 0.0001 | 0.0031 |
A/A–G/G | 177 (52.1) | 114 (65.1) | 1 | |||||
LPHN3 | rs2305339 | Overdominant | A/G | 163 (47.9) | 61 (34.9) | 0.51 (0.34–0.76) | 0.0008 | 0.0124 |
Male | ||||||||
A/A | 83 (36.9) | 128 (55.2) | 1 | |||||
LPHN3 | rs2305339 | Codominant | A/G | 128 (56.9) | 81 (34.9) | 0.41 (0.28 –0.60) | 0.0000 | 0.0001 |