Fig. 2From: Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorderConnections of brain regions implicated in both social and repetitive behaviors. Activation of projection from the amygdala to the hippocampus increases repetitive self-grooming behavior, yet decreasing social behaviors [61]. Optogenetic disruption of E/I balance of the PFC impairs social behaviors [77]. Inhibition of the PFC projection to the VTA reduces repetitive behaviors and activation of the projection from the PFC to the SNc induces hyperactivity [72, 81]. Dopaminergic projections from the VTA to the ventral striatum, a key region implicated in motivation is necessary for social reward [82]. SNc substantia nigra pars compacta, PFC prefrontal cortex, VTA ventral tegmental areaBack to article page