Fig. 3

Meta-analytic connectivity modeling (MACM) maps of task-related co-activation for each structurally impacted ROI. These thresholded MACM maps (p _corrected  < 0.05) represent voxels with an above-chance probability of co-activating with the respective seed regions (8 mm radius spheres centered on the voxels with maximum ALE values within each smoking-related gray matter loss region). One region (ROI 8; mOFC) failed to return a sufficient number of contrasts from the database and was omitted from further analyses. Numbering corresponds to that in Table 1. The seed ROI of each MACM map is outlined in red. MACM maps for ROIs boxed in red are discussed in the main text. See Additional file 1: Table S4 for each seed ROI’s co-activation coordinates