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Table 2 Conjoint chronic smoking-related structural alterations and acute drug-induced functional activity changes: cluster coordinates

From: Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations

Cluster

Region

Volume

X

Y

Z

Gray matter decreases ∩ functional decreases

a

Insula (BA 13)

L

185

−39

7

9

b

vmPFC (BA10) (superior frontal gyrus)

L

103

−9

50

−3

Gray matter decreases ∩ functional increases

c

Thalamus (medial dorsal nucleus)

B

142

2

−14

11

  1. Lettering corresponds to brain regions shown in Fig. 2. Coordinates (X, Y, Z) of the clusters’ peak voxels are reported in Talairach space. Volume is mm3
  2. B bilateral, R right, L left, BA Brodmann area, vmPFC ventromedial prefrontal cortex