Association between C3435T polymorphism of MDR1 gene and the incidence of drug-resistant epilepsy in the population of Polish children

Table 4 Distributions of TT, CT and CC genotypes and T and C alleles in C3435T polymorphism of MDR1 gene in the group of children with drug-resistant epilepsy and in the group of drug-responsive epilepsy

	Children with drug-resistant epilepsy (n = 106)		Children with drug-responsive epilepsy (n = 67)		OR (95 % CI^a)^b	p ^c
	Number	(%)	Number	(%)	OR (95 % CI^a)^b	p ^c
CC	35	33	16	24	1.00 Ref.^d
CT	39	37	18	27	0.99 (0.44–2.23)	0.862
TT	32	30	33	49	0.44 (0.21–0.95)	0.036
C	109	51	50	37	1.00 Ref.
T	103	49	84	63	0.56 (0.36–0.87)	0.014

^aAnalysis of odds ratio (OR odds ratio, PU Confidence Interval 95 %)
^bAdjusted for age and use of variety of drugs
^cFor the test of χ² conformity with the distribution predicted by the Hardy–Weinberg law
^dReference group—wild type of allele

ISSN: 1744-9081