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Table 2 Associations between the plasma metabolites and ADHD-like behavioural scores (total ADHD, inattention, impulsivity)

From: A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs

Putative annotation Total ADHD Inattention Impulsivity
rs praw pFDR rs praw pFDR rs praw pFDR
Putative carnitine 0.505 0.017 0.990 0.450 0.036 0.990 0.509 0.016 0.797
1-methylnicotinamide 0.647 0.001 0.618 0.668 6.86E-04 0.455 0.571 0.005 0.461
Kynurenic acid (KYNA) 0.511 0.015 0.426 0.505 0.017 0.392 0.498 0.018 0.447
Phelynalanine 0.403 ns ns 0.337 ns ns 0.425 0.049 0.989
Indoleacetic acid −0.404 ns ns −0.474 0.030 0.433 −0.349 ns ns
3-Indolepropionic acid (IPA) −0.565 0.006 0.381 −0.618 0.002 0.241 −0.452 0.035 0.560
Unknown metabolite m/z 221.150 0.443 0.039 0.990 0.520 0.013 0.873 0.287 ns ns
sn-1 LysoPC(14:0) −0.390 ns ns −0.424 0.049 0.510 −0.360 ns ns
sn-1 LysoPC(18:3) −0.769 2.93E-05 0.016 −0.740 8.26E-05 0.030 −0.765 3.32E-05 0.036
sn-1 LysoPE(20:5) −0.544 0.009 0.409 −0.615 0.002 0.241 −0.447 0.037 0.560
sn-1 LysoPC(15:0) −0.623 0.002 0.330 −0.602 0.003 0.241 −0.659 8.46E-04 0.320
sn-1 LysoPE(18:2) −0.630 0.002 0.093 −0.697 3.1E-04 0.044 −0.549 0.008 0.230
sn-1 LysoPE(18:1) −0.382 ns ns −0.530 0.011 0.117 −0.218 ns ns
sn-1 LysoPC(20:3) −0.508 0.016 0.426 −0.489 0.021 0.409 −0.516 0.014 0.437
sn-1 LysoPC(17:0) −0.451 0.035 0.491 −0.438 0.041 0.473 −0.441 0.038 0.566
sn-1 LysoPE(18:0) −0.562 0.006 0.146 −0.574 0.005 0.102 −0.539 0.01 0.232
Arachidonic acid (C20:4) 0.508 0.016 0.163 0.579 0.005 0.102 0.355 ns ns
Unknown metabolite, putative GlcCer(d18:1/12:0) or GlcCer(d14:1/16:0) 0.504 0.017 0.163 0.524 0.012 0.117 0.447 0.037 0.302
C18:1 0.509 0.016 0.426 0.532 0.011 0.342 0.477 0.025 0.492
Unknown metabolite, putative Cer(d18:1/24:1) 0.509 0.016 0.163 0.536 0.010 0.117 0.461 0.031 0.283
Bilirubin 0.513 0.015 0.426 0.580 0.005 0.271 0.452 0.035 0.560
PC(20:5/18:3) −0.555 0.009 0.150 −0.621 0.003 0.087 −0.415 ns ns
Unknown PC m/z 796.516 −0.413 ns ns −0.465 0.029 0.173 −0.299 ns ns
PC(20:4/14:0) −0.558 0.007 0.148 −0.557 0.007 0.110 −0.485 0.022 0.281
PC(18:3/18:2) −0.804 1.91E-05 0.016 −0.798 2.53E-05 0.019 −0.731 2.52E-04 0.137
PC(18:2/16:1) −0.518 0.013 0.163 −0.500 0.018 0.137 −0.486 0.022 0.281
PC(15:0/18:2) −0.578 0.005 0.381 −0.568 0.006 0.305 −0.525 0.012 0.416
  1. Spearman correlation coefficients (rs) with statistical significance (praw and pFDR)
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Behavioral and Brain Functions

ISSN: 1744-9081

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