A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs

Jenni Puurunen; Sini Sulkama; Katriina Tiira; Cesar Araujo; Marko Lehtonen; Kati Hanhineva; Hannes Lohi

doi:10.1186/s12993-016-0112-1

Table 2 Associations between the plasma metabolites and ADHD-like behavioural scores (total ADHD, inattention, impulsivity)

From: A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs

Putative annotation	Total ADHD			Inattention			Impulsivity
Putative annotation	r_s	p_raw	pFDR	r_s	p_raw	pFDR	r_s	p_raw	pFDR
Putative carnitine	0.505	0.017	0.990	0.450	0.036	0.990	0.509	0.016	0.797
1-methylnicotinamide	0.647	0.001	0.618	0.668	6.86E-04	0.455	0.571	0.005	0.461
Kynurenic acid (KYNA)	0.511	0.015	0.426	0.505	0.017	0.392	0.498	0.018	0.447
Phelynalanine	0.403	ns	ns	0.337	ns	ns	0.425	0.049	0.989
Indoleacetic acid	−0.404	ns	ns	−0.474	0.030	0.433	−0.349	ns	ns
3-Indolepropionic acid (IPA)	−0.565	0.006	0.381	−0.618	0.002	0.241	−0.452	0.035	0.560
Unknown metabolite m/z 221.150	0.443	0.039	0.990	0.520	0.013	0.873	0.287	ns	ns
sn-1 LysoPC(14:0)	−0.390	ns	ns	−0.424	0.049	0.510	−0.360	ns	ns
sn-1 LysoPC(18:3)	−0.769	2.93E-05	0.016	−0.740	8.26E-05	0.030	−0.765	3.32E-05	0.036
sn-1 LysoPE(20:5)	−0.544	0.009	0.409	−0.615	0.002	0.241	−0.447	0.037	0.560
sn-1 LysoPC(15:0)	−0.623	0.002	0.330	−0.602	0.003	0.241	−0.659	8.46E-04	0.320
sn-1 LysoPE(18:2)	−0.630	0.002	0.093	−0.697	3.1E-04	0.044	−0.549	0.008	0.230
sn-1 LysoPE(18:1)	−0.382	ns	ns	−0.530	0.011	0.117	−0.218	ns	ns
sn-1 LysoPC(20:3)	−0.508	0.016	0.426	−0.489	0.021	0.409	−0.516	0.014	0.437
sn-1 LysoPC(17:0)	−0.451	0.035	0.491	−0.438	0.041	0.473	−0.441	0.038	0.566
sn-1 LysoPE(18:0)	−0.562	0.006	0.146	−0.574	0.005	0.102	−0.539	0.01	0.232
Arachidonic acid (C20:4)	0.508	0.016	0.163	0.579	0.005	0.102	0.355	ns	ns
Unknown metabolite, putative GlcCer(d18:1/12:0) or GlcCer(d14:1/16:0)	0.504	0.017	0.163	0.524	0.012	0.117	0.447	0.037	0.302
C18:1	0.509	0.016	0.426	0.532	0.011	0.342	0.477	0.025	0.492
Unknown metabolite, putative Cer(d18:1/24:1)	0.509	0.016	0.163	0.536	0.010	0.117	0.461	0.031	0.283
Bilirubin	0.513	0.015	0.426	0.580	0.005	0.271	0.452	0.035	0.560
PC(20:5/18:3)	−0.555	0.009	0.150	−0.621	0.003	0.087	−0.415	ns	ns
Unknown PC m/z 796.516	−0.413	ns	ns	−0.465	0.029	0.173	−0.299	ns	ns
PC(20:4/14:0)	−0.558	0.007	0.148	−0.557	0.007	0.110	−0.485	0.022	0.281
PC(18:3/18:2)	−0.804	1.91E-05	0.016	−0.798	2.53E-05	0.019	−0.731	2.52E-04	0.137
PC(18:2/16:1)	−0.518	0.013	0.163	−0.500	0.018	0.137	−0.486	0.022	0.281
PC(15:0/18:2)	−0.578	0.005	0.381	−0.568	0.006	0.305	−0.525	0.012	0.416

Spearman correlation coefficients (r_s) with statistical significance (p_raw and pFDR)

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