A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs

Puurunen, Jenni; Sulkama, Sini; Tiira, Katriina; Araujo, Cesar; Lehtonen, Marko; Hanhineva, Kati; Lohi, Hannes

doi:10.1186/s12993-016-0112-1

Table 3 Age, sex and fasting-adjusted associations between the plasma metabolites and ADHD-like behavioural scores

From: A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs

Putative annotation	Total ADHD			Inattention			Impulsivity
	Original	Adjusted		Original	Adjusted		Original	Adjusted
	p	r_s	p	p	r_s	p	p	r_s	p
Putative carnitine	0.017	0.560	0.013	0.036	0.527	0.02	0.016	0.526	0.021
1-methylnicotinamide	0.001	0.642	0.003	6.86E-04	0.671	0.002	0.005	0.576	0.010
Kynurenic acid (KYNA)	0.015	0.519	0.023	0.017	0.486	0.035	0.018	0.543	0.016
Phelynalanine	ns	ns	ns	ns	ns	ns	0.049	0.435	0.063
Indoleacetic acid	ns	ns	ns	0.030	−0.448	0.062	ns	ns	ns
3-Indolepropionic acid (IPA)	0.006	−0.578	0.010	0.002	−0.655	0.002	0.035	−0.442	0.058
Unknown metabolite m/z 221.150	0.039	0.426	0.069	0.013	0.475	0.040	ns	ns	ns
sn-1 LysoPC(14:0)	ns	ns	ns	0.049	−0.387	0.102	ns	ns	ns
sn-1 LysoPC(18:3)	2.93E-05	−0.782	7.54E-05	8.26E-05	−0.765	1.34E-04	3.32E-05	−0.785	6.86E-05
sn-1 LysoPE(20:5)	0.009	−0.569	0.011	0.002	−0.615	0.005	0.037	−0.499	0.030
sn-1 LysoPC(15:0)	0.002	−0.640	0.003	0.003	−0.598	0.007	8.46E-04	−0.701	8.0E-04
sn-1 LysoPE(18:2)	0.002	−0.670	0.002	0.003	−0.703	8.0E-04	0.008	−0.645	0.003
sn-1 LysoPE(18:1)	ns	ns	ns	0.011	−0.493	0.032	ns	ns	ns
sn-1 LysoPC(20:3)	0.016	−0.550	0.015	0.021	−0.555	0.014	0.014	−0.561	0.013
sn-1 LysoPC(17:0)	0.035	−0.463	0.046	0.041	−0.447	0.055	0.038	−0.499	0.030
sn-1 LysoPE(18:0)	0.006	−0.610	0.006	0.005	−0.622	0.004	0.01	−0.600	0.007
Arachidonic acid (C20:4)	0.016	0.502	0.029	0.005	0.555	0.014	ns	ns	ns
Unknown metabolite, putative GlcCer(d18:1/12:0) or GlcCer(d14:1/16:0)	0.017	0.514	0.024	0.012	0.547	0.015	0.037	0.473	0.041
C18:1	0.016	0.508	0.026	0.011	0.524	0.021	0.025	0.505	0.028
Unknown metabolite, putative Cer(d18:1/24:1)	0.016	0.506	0.027	0.010	0.529	0.020	0.031	0.488	0.034
Bilirubin	0.015	0.511	0.025	0.005	0.544	0.016	0.035	0.515	0.024
PC(20:5/18:3)	0.009	−0.601	0.008	0.003	−0.615	0.007	ns	ns	ns
Unknown PC m/z 796.516	ns	ns	ns	0.029	−0.404	0.087	ns	ns	ns
PC(20:4/14:0)	0.007	−0.559	0.013	0.007	−0.538	0.017	0.022	−0.531	0.019
PC(18:3/18:2)	1.19E-05	−0.804	9.91E-05	2.53E-05	−0.785	1.89E-04	2.52E-04	−0.767	3.24E-04
PC(18:2/16:1)	0.013	−0.529	0.020	0.018	−0.537	0.018	0.022	−0.476	0.039
PC(15:0/18:2)	0.005	−0.604	0.006	0.006	−0.578	0.010	0.012	−0.590	0.008

Spearman correlation coefficients (corrected r_s) from partial correlation analysis including age, sex and fasting status as covariates together with statistical significance (adjusted p). Original p values are also shown (original p)

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