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Table 3 Age, sex and fasting-adjusted associations between the plasma metabolites and ADHD-like behavioural scores

From: A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs

Putative annotation Total ADHD Inattention Impulsivity
Original Adjusted Original Adjusted Original Adjusted
p rs p p rs p p rs p
Putative carnitine 0.017 0.560 0.013 0.036 0.527 0.02 0.016 0.526 0.021
1-methylnicotinamide 0.001 0.642 0.003 6.86E-04 0.671 0.002 0.005 0.576 0.010
Kynurenic acid (KYNA) 0.015 0.519 0.023 0.017 0.486 0.035 0.018 0.543 0.016
Phelynalanine ns ns ns ns ns ns 0.049 0.435 0.063
Indoleacetic acid ns ns ns 0.030 −0.448 0.062 ns ns ns
3-Indolepropionic acid (IPA) 0.006 −0.578 0.010 0.002 −0.655 0.002 0.035 −0.442 0.058
Unknown metabolite m/z 221.150 0.039 0.426 0.069 0.013 0.475 0.040 ns ns ns
sn-1 LysoPC(14:0) ns ns ns 0.049 −0.387 0.102 ns ns ns
sn-1 LysoPC(18:3) 2.93E-05 −0.782 7.54E-05 8.26E-05 −0.765 1.34E-04 3.32E-05 −0.785 6.86E-05
sn-1 LysoPE(20:5) 0.009 −0.569 0.011 0.002 −0.615 0.005 0.037 −0.499 0.030
sn-1 LysoPC(15:0) 0.002 −0.640 0.003 0.003 −0.598 0.007 8.46E-04 −0.701 8.0E-04
sn-1 LysoPE(18:2) 0.002 −0.670 0.002 0.003 −0.703 8.0E-04 0.008 −0.645 0.003
sn-1 LysoPE(18:1) ns ns ns 0.011 −0.493 0.032 ns ns ns
sn-1 LysoPC(20:3) 0.016 −0.550 0.015 0.021 −0.555 0.014 0.014 −0.561 0.013
sn-1 LysoPC(17:0) 0.035 −0.463 0.046 0.041 −0.447 0.055 0.038 −0.499 0.030
sn-1 LysoPE(18:0) 0.006 −0.610 0.006 0.005 −0.622 0.004 0.01 −0.600 0.007
Arachidonic acid (C20:4) 0.016 0.502 0.029 0.005 0.555 0.014 ns ns ns
Unknown metabolite, putative GlcCer(d18:1/12:0) or GlcCer(d14:1/16:0) 0.017 0.514 0.024 0.012 0.547 0.015 0.037 0.473 0.041
C18:1 0.016 0.508 0.026 0.011 0.524 0.021 0.025 0.505 0.028
Unknown metabolite, putative Cer(d18:1/24:1) 0.016 0.506 0.027 0.010 0.529 0.020 0.031 0.488 0.034
Bilirubin 0.015 0.511 0.025 0.005 0.544 0.016 0.035 0.515 0.024
PC(20:5/18:3) 0.009 −0.601 0.008 0.003 −0.615 0.007 ns ns ns
Unknown PC m/z 796.516 ns ns ns 0.029 −0.404 0.087 ns ns ns
PC(20:4/14:0) 0.007 −0.559 0.013 0.007 −0.538 0.017 0.022 −0.531 0.019
PC(18:3/18:2) 1.19E-05 −0.804 9.91E-05 2.53E-05 −0.785 1.89E-04 2.52E-04 −0.767 3.24E-04
PC(18:2/16:1) 0.013 −0.529 0.020 0.018 −0.537 0.018 0.022 −0.476 0.039
PC(15:0/18:2) 0.005 −0.604 0.006 0.006 −0.578 0.010 0.012 −0.590 0.008
  1. Spearman correlation coefficients (corrected rs) from partial correlation analysis including age, sex and fasting status as covariates together with statistical significance (adjusted p). Original p values are also shown (original p)