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Fig. 2 | Behavioral and Brain Functions

Fig. 2

From: Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos

Fig. 2

Top panel: social conditioned place preference test. Mean preference for the bedding that was conditioned with another conspecific. Individual mice are shown as symbols (Δ male O female). All mice are offspring, aged 90 days, of dams that were given CPF (2.5 or 5 mg/kg) or peanut oil vehicle by gavage on GD 12–15. The main effect of treatment is depicted by the thin triple bracket, indicating that the vehicle exposed group showed a larger change in preference than each of the CPF-exposed groups (p = .006). The thick bracket indicates the main effect of sex (p = .015). Male: vehicle: n = 16, 2.5 mg/kg: n = 8, 5 mg/kg: n = 15, female: n = 3 in each group. Bottom panel: food conditioned place preference test. Mean preference for the bedding that was conditioned with an appetitive stimulus reward. Individual mice are shown as symbols (Δ male O female). All mice are offspring aged 90 days of dams, that were given CPF (2.5 or 5 mg/kg) or peanut oil vehicle by gavage on GD 12–15. The significant comparisons are depicted by dashed brackets (p = .001) or double bracket (p < .05). Male: vehicle: n = 11, 2.5 mg/kg: n = 8, 5 mg/kg: n = 12, female: vehicle: n = 8, 2.5 mg/kg: n = 7. 5 mg/kg: n = 5

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